Cytosine methylation and human cancer
PM Warnecke, TH Bestor - Current opinion in oncology, 2000 - journals.lww.com
Abnormalities of genomic methylation patterns have been attributed a role in carcinogenesis
since the early 1980s, when large-scale demethylation of the genome was thought be an …
since the early 1980s, when large-scale demethylation of the genome was thought be an …
Reduced genomic 5-methylcytosine content in human colonic neoplasia
AP Feinberg, CW Gehrke, KC Kuo, M Ehrlich - Cancer research, 1988 - AACR
DNA methylation appears to play an important role in both physiological and experimentally
modified gene expression, and alterations in DNA methylation have been described in …
modified gene expression, and alterations in DNA methylation have been described in …
Unanswered questions about the role of promoter methylation in carcinogenesis
TH Bestor - Annals of the New York Academy of Sciences, 2003 - Wiley Online Library
It has been proposed that tumor suppressor genes can be silenced by ectopic de novo
methylation during tumor progression and that this epigenetic silencing is an alternative to …
methylation during tumor progression and that this epigenetic silencing is an alternative to …
[引用][C] Alterations in DNA methylation may play a variety of roles in carcinogenesis
JL Counts, JI Goodman - Cell, 1995 - Elsevier
There is considerable interest in the role that DNA methylation (5-methylcytosine [5MeC]
content of DNA) plays in both normal development (Razin and Kafri, 1994) and …
content of DNA) plays in both normal development (Razin and Kafri, 1994) and …
DNA methylation in health, disease, and cancer
DS Shames, JD Minna… - Current molecular …, 2007 - ingentaconnect.com
The spatial arrangement and three-dimensional structure of DNA in the nucleus is controlled
through the interdigitation of DNA binding proteins such as histones and their modifiers, the …
through the interdigitation of DNA binding proteins such as histones and their modifiers, the …
The role of DNA methylation in cancer genetics and epigenetics
PW Laird, R Jaenisch - Annual review of genetics, 1996 - annualreviews.org
▪ Abstract The past few years have seen a wider acceptance of a role for DNA methylation in
cancer. This can be attributed to three developments. First, the documentation of the over …
cancer. This can be attributed to three developments. First, the documentation of the over …
The role of DNA methylation in cancer
PA Jones, JD Buckley - Advances in cancer research, 1990 - Elsevier
Publisher Summary This chapter discusses the role of DNA methylation in carcinogenesis
and tumor diversification. The methylation of HpaII and Hha1 sites in DNA isolated from the …
and tumor diversification. The methylation of HpaII and Hha1 sites in DNA isolated from the …
[HTML][HTML] DNA methylation in breast and colorectal cancers
A Agrawal, RF Murphy, DK Agrawal - Modern Pathology, 2007 - Elsevier
DNA methylation is one of several epigenetic changes observed in cells. Aberrant
methylation of tumor suppressor genes, proto-oncogenes, and vital cell cycle genes has led …
methylation of tumor suppressor genes, proto-oncogenes, and vital cell cycle genes has led …
Global and gene-specific methylation patterns in cancer: aspects of tumor biology and clinical potential
MC Frühwald, C Plass - Molecular genetics and metabolism, 2002 - Elsevier
Heritable alterations of DNA that do not affect the base pair sequence itself but nevertheless
regulate the predetermined activity of genes are referred to as epigenetic. Epigenetic …
regulate the predetermined activity of genes are referred to as epigenetic. Epigenetic …
DNA hypomethylation and hemimethylation in cancer
In contrast to earlier views that there was much compartmentalization of the types of
sequences subject to cancer-linked changes in DNA epigenetics, it is now clear that both …
sequences subject to cancer-linked changes in DNA epigenetics, it is now clear that both …