Abnormalities of genomic methylation patterns have been attributed a role in carcinogenesis
since the early 1980s, when large-scale demethylation of the genome was thought be an …

DNA methylation appears to play an important role in both physiological and experimentally
modified gene expression, and alterations in DNA methylation have been described in …

There is considerable interest in the role that DNA methylation (5-methylcytosine [5MeC]
content of DNA) plays in both normal development (Razin and Kafri, 1994) and …

It has been proposed that tumor suppressor genes can be silenced by ectopic de novo
methylation during tumor progression and that this epigenetic silencing is an alternative to …

▪ Abstract The past few years have seen a wider acceptance of a role for DNA methylation in
cancer. This can be attributed to three developments. First, the documentation of the over …

The spatial arrangement and three-dimensional structure of DNA in the nucleus is controlled
through the interdigitation of DNA binding proteins such as histones and their modifiers, the …

DNA methylation is one of several epigenetic changes observed in cells. Aberrant
methylation of tumor suppressor genes, proto-oncogenes, and vital cell cycle genes has led …

Publisher Summary This chapter discusses the role of DNA methylation in carcinogenesis
and tumor diversification. The methylation of HpaII and Hha1 sites in DNA isolated from the …

Heritable alterations of DNA that do not affect the base pair sequence itself but nevertheless
regulate the predetermined activity of genes are referred to as epigenetic. Epigenetic …

In contrast to earlier views that there was much compartmentalization of the types of
sequences subject to cancer-linked changes in DNA epigenetics, it is now clear that both …