DNA methylation patterns in lung carcinomas
GP Pfeifer, TA Rauch - Seminars in cancer biology, 2009 - Elsevier
The genome of epithelial tumors is characterized by numerous chromosomal aberrations,
DNA base sequence changes, and epigenetic abnormalities. The epigenome of cancer cells …
DNA base sequence changes, and epigenetic abnormalities. The epigenome of cancer cells …
High-resolution mapping of DNA hypermethylation and hypomethylation in lung cancer
Changes in DNA methylation patterns are an important characteristic of human cancer.
Tumors have reduced levels of genomic DNA methylation and contain hypermethylated …
Tumors have reduced levels of genomic DNA methylation and contain hypermethylated …
[HTML][HTML] Genome-wide DNA methylation analyses in lung adenocarcinomas: Association with EGFR, KRAS and TP53 mutation status, gene expression and prognosis
MM Bjaanæs, T Fleischer, AR Halvorsen, A Daunay… - Molecular …, 2016 - Elsevier
Background DNA methylation alterations are early events in tumorigenesis and important in
the regulation of gene expression in cancer cells. Lung cancer patients have in general a …
the regulation of gene expression in cancer cells. Lung cancer patients have in general a …
Genome-wide CpG island methylation analyses in non-small cell lung cancer patients
G Heller, VN Babinsky, B Ziegler, M Weinzierl… - …, 2013 - academic.oup.com
DNA methylation is part of the epigenetic gene regulation complex, which is relevant for the
pathogenesis of cancer. We performed a genome-wide search for methylated CpG islands …
pathogenesis of cancer. We performed a genome-wide search for methylated CpG islands …
DNA methylation biomarkers for lung cancer
Abstract Changes in DNA methylation patterns are an important characteristic of human
cancer including lung cancer. In particular, hypermethylation of CpG islands is a signature of …
cancer including lung cancer. In particular, hypermethylation of CpG islands is a signature of …
Identification of CpG islands hypermethylated in human lung cancer by the arbitrarily primed-PCR method
DNA hypermethylation is believed to be involved in human carcinogenesis, since it
suppresses the transcription of defined genes and is associated with chromosomal …
suppresses the transcription of defined genes and is associated with chromosomal …
HOX gene clusters are hotspots of de novo methylation in CpG islands of human lung adenocarcinomas
M Shiraishi, A Sekiguchi, AJ Oates, MJ Terry… - Oncogene, 2002 - nature.com
CpG island methylation results in the silencing of the associated gene and is an important
step in tumorigenesis. Following a comprehensive isolation of CpG islands that were …
step in tumorigenesis. Following a comprehensive isolation of CpG islands that were …
Multiple gene methylation of nonsmall cell lung cancers evaluated with 3‐dimensional microarray
Y Wang, D Zhang, W Zheng, J Luo… - … International Journal of …, 2008 - Wiley Online Library
BACKGROUND Aberrant DNA methylation of the CpG islands for cancer‐related genes is
among the earliest and most frequent alterations in cancer and may be useful for diagnosing …
among the earliest and most frequent alterations in cancer and may be useful for diagnosing …
Hierarchical clustering of lung cancer cell lines using DNA methylation markers
AK Virmani, JA Tsou, KD Siegmund, LYC Shen… - … Biomarkers & Prevention, 2002 - AACR
Recent analyses of global and gene-specific methylation patterns in cancer cells have
suggested that cancers from different organs demonstrate distinct patterns of CpG island …
suggested that cancers from different organs demonstrate distinct patterns of CpG island …
DNA methylation differences associated with tumor tissues identified by genome scanning analysis
Most investigations on the role of DNA methylation in cancer have focused on epigenetic
changes associated with known tumor suppressor genes. This may have led to an …
changes associated with known tumor suppressor genes. This may have led to an …