Background: DNA methylation is involved in many gene functions such as gene‐silencing, X‐
inactivation, imprinting and stability of the gene. We recently found that some CpG islands …

The study on DNA methylation pattern in different human tissues attracts increasing interest
nowadays, but a systematic analysis of CpG island methylation pattern between both …

Differentiation of embryonic stem (ES) cells into embryoid bodies (EBs) provides an in vitro
system for the study of early lineage determination during mammalian development. We …

DNA methylation has been implicated in mammalian development. Transcription units
contain CpG islands, but expression of CpG island associated genes in normal tissues was …

The role of CpG island methylation in normal development and cell differentiation is of keen
interest, but remains poorly understood. We performed comprehensive DNA methylation …

Methylation of DNA, which occurs at cytosines of CpG sequences, is a unique chemical
modification of the vertebrate genome. Methylation patterns can be copied to daughter DNA …

A large number of studies have documented the methylation patterns of individual genes
and repeated sequences in different tissues of various mammalian species. This has …

Many CpG islands have tissue-dependent and differentially methylated regions (T-DMRs) in
normal cells and tissues. To elucidate how DNA methyltransferases (Dnmts) participate in …

DNA methylation plays a role in the repression of gene expression in animal cells. In the
mouse preimplantation embryo, most genes are unmethylated but a wave of de novo …

DNA methylation is a repressive epigenetic modification that covers vertebrate genomes.
Regions known as CpG islands (CGIs), which are refractory to DNA methylation, are often …