Promoter DNA methylation, which occurs on cytosine nucleotides across CpG islands,
results in gene silencing and represents a major epigenetic alteration in human cancer …

Carcinogenesis is accompanied by widespread DNA methylation changes within the cell.
These changes are characterized by a globally hypomethylated genome with focal …

Alterations in DNA methylation, which are associated with DNA methyltransferase
abnormalities and result in silencing of tumor-related genes and chromosomal instability …

DNA methylation was the first epigenetic modification to be detected in human cancers with
specific relation to aberrant gene expression. Herein, DNA methylation analysis explains …

DNA methylation occurs at the CpG residues and serves as a powerful epigenetic
mechanism that negatively regulates gene expression. This process is catalyzed by DNA …

DNA methylation, the addition of a methyl group to the carbon-5 position of cytosine
residues, is the only common covalent modification of human DNA and occurs almost …

Background Epigenetic gene silencing is one of the major causes of carcinogenesis. Its
widespread occurrence in cancer genome could inactivate many cellular pathways …

Background Epigenetic alteration of gene expression is a common event in human cancer.
DNA methylation is a well-known epigenetic process, but verifying the exact nature of …

Altered epigenetic regulation is central to many human diseases, including cancer. Over the
past two decade, major advances have been made in our understanding of the role of …

Alterations of DNA methylation, which result in chromosomal instability and silencing of
tumor‐related genes, are among the most consistent epigenetic changes observed in …