Because nucleosomes are widely replaced by protamine in mature human sperm, the
epigenetic contributions of sperm chromatin to embryo development have been considered …

DNA methylation is a crucial element in the epigenetic regulation of mammalian embryonic
development,,,,. However, its dynamic patterns have not been analysed at the genome scale …

Mammalian sperm and oocytes have different epigenetic landscapes and are organized in
different fashions. After fertilization, the initially distinct parental epigenomes become largely …

Histone modifications have critical roles in regulating the expression of developmental
genes during embryo development in mammals,. However, genome-wide analyses of …

In higher eukaryotes, histone methylation is involved in maintaining cellular identity during
somatic development. As most nucleosomes are replaced by protamines during …

INTRODUCTION Despite the father transmitting half of the heritable information to the
embryo, the focus of preconception health has been the mother. Paternal effects have been …

DNA methylation is highly dynamic during mammalian embryogenesis. It is broadly
accepted that the paternal genome is actively depleted of 5-methylcytosine at fertilization …

Histone modifications are fundamental epigenetic regulators that control many crucial
cellular processes. However, whether these marks can be passed on from mammalian …

In mammals, both parental genomes undergo dramatic epigenetic changes after fertilization
to form the diploid somatic genome. Here we show that the paternal genome in the mouse is …

Even though the genetic fingerprint of human sperm has been defined, its role in
orchestrating fertilization and the development of the early embryo remains vague. Here we …