Distinctive chromatin in human sperm packages genes for embryo development
SS Hammoud, DA Nix, H Zhang, J Purwar, DT Carrell… - Nature, 2009 - nature.com
Because nucleosomes are widely replaced by protamine in mature human sperm, the
epigenetic contributions of sperm chromatin to embryo development have been considered …
epigenetic contributions of sperm chromatin to embryo development have been considered …
The DNA methylation landscape of human early embryos
H Guo, P Zhu, L Yan, R Li, B Hu, Y Lian, J Yan, X Ren… - Nature, 2014 - nature.com
DNA methylation is a crucial element in the epigenetic regulation of mammalian embryonic
development,,,,. However, its dynamic patterns have not been analysed at the genome scale …
development,,,,. However, its dynamic patterns have not been analysed at the genome scale …
Maternal H3K27me3 controls DNA methylation-independent imprinting
Mammalian sperm and oocytes have different epigenetic landscapes and are organized in
different fashions. After fertilization, the initially distinct parental epigenomes become largely …
different fashions. After fertilization, the initially distinct parental epigenomes become largely …
Distinct features of H3K4me3 and H3K27me3 chromatin domains in pre-implantation embryos
Histone modifications have critical roles in regulating the expression of developmental
genes during embryo development in mammals,. However, genome-wide analyses of …
genes during embryo development in mammals,. However, genome-wide analyses of …
Repressive and active histone methylation mark distinct promoters in human and mouse spermatozoa
U Brykczynska, M Hisano, S Erkek, L Ramos… - Nature structural & …, 2010 - nature.com
In higher eukaryotes, histone methylation is involved in maintaining cellular identity during
somatic development. As most nucleosomes are replaced by protamines during …
somatic development. As most nucleosomes are replaced by protamines during …
Disruption of histone methylation in developing sperm impairs offspring health transgenerationally
INTRODUCTION Despite the father transmitting half of the heritable information to the
embryo, the focus of preconception health has been the mother. Paternal effects have been …
embryo, the focus of preconception health has been the mother. Paternal effects have been …
A unique regulatory phase of DNA methylation in the early mammalian embryo
DNA methylation is highly dynamic during mammalian embryogenesis. It is broadly
accepted that the paternal genome is actively depleted of 5-methylcytosine at fertilization …
accepted that the paternal genome is actively depleted of 5-methylcytosine at fertilization …
Allelic reprogramming of the histone modification H3K4me3 in early mammalian development
Histone modifications are fundamental epigenetic regulators that control many crucial
cellular processes. However, whether these marks can be passed on from mammalian …
cellular processes. However, whether these marks can be passed on from mammalian …
Demethylation of the zygotic paternal genome
W Mayer, A Niveleau, J Walter, R Fundele, T Haaf - Nature, 2000 - nature.com
In mammals, both parental genomes undergo dramatic epigenetic changes after fertilization
to form the diploid somatic genome. Here we show that the paternal genome in the mouse is …
to form the diploid somatic genome. Here we show that the paternal genome in the mouse is …
Delivering spermatozoan RNA to the oocyte
GC Ostermeier, D Miller, JD Huntriss, MP Diamond… - Nature, 2004 - nature.com
Even though the genetic fingerprint of human sperm has been defined, its role in
orchestrating fertilization and the development of the early embryo remains vague. Here we …
orchestrating fertilization and the development of the early embryo remains vague. Here we …