Birth asphyxia and the resulting hypoxic-ischemic encephalopathy (HIE) are highly
associated with perinatal and neonatal death, neonatal seizures, and an adverse later-life …

Objective Neonatal seizures are the most frequent type of neurological emergency in
newborn infants, often being a consequence of prolonged perinatal asphyxia. Phenobarbital …

Objectives Bumetanide was suggested as an adjunct to phenobarbital for suppression of
neonatal seizures. This suggestion was based on the idea that bumetanide, by reducing …

Kaila, Löscher, and colleagues report that phenobarbital (PHB) and midazolam (MDZ)
attenuate neonatal seizures following birth asphyxia, but the former only when applied …

Loop diuretics such as furosemide and bumetanide, which act by inhibiting the Na-K-2Cl
cotransporter NKCC2 at the thick ascending limb of the loop of Henle, have been shown to …

Objective Birth asphyxia (BA) is the most frequent cause of neonatal death as well as central
nervous system (CNS) injury. BA is often associated with neonatal seizures, which only …

Neonatal seizures can be refractory to conventional anticonvulsants, and this may in part be
due to a developmental increase in expression of the neuronal Na+-K+-2 Cl− cotransporter …

The immature brain has a higher susceptibility to develop seizures, which often respond
poorly to classical pharmacological treatment. It has been recently suggested that …

Neonatal seizures caused by perinatal asphyxia and hypoxic–ischemic encephalopathy can
be refractory to conventional anticonvulsants. This may be due to the depolarizing effects of …

In this response to a commentary by Ben‐Ari and Delpire on our recent study on the
pharmacology of neonatal seizures in a novel, physiologically validated rat model of birth …