Mutant p53 and aberrant cytosine methylation cooperate to silence gene expression
MM Oshiro, GS Watts, RJ Wozniak, DJ Junk… - Oncogene, 2003 - nature.com
Abstract p53 is an important transcriptional regulator that is frequently mutated in cancer.
Gene-profiling experiments of breast cancer cells infected with wt p53 revealed both …
Gene-profiling experiments of breast cancer cells infected with wt p53 revealed both …
Enhancement of antineoplastic action of 5-aza-2′-deoxycytidine by zebularine on L1210 leukemia
M Lemaire, LF Momparler, ML Bernstein… - Anti-cancer …, 2005 - journals.lww.com
Tumor suppressor genes that have been silenced by aberrant DNA methylation are potential
targets for reactivation by novel chemotherapeutic agents. The potent inhibitor of DNA …
targets for reactivation by novel chemotherapeutic agents. The potent inhibitor of DNA …
DNA demethylation by 5-aza-2′-deoxycytidine is imprinted, targeted to euchromatin, and has limited transcriptional consequences
Background DNA methylation can be abnormally regulated in human disease and
associated with effects on gene transcription that appear to be causally related to …
associated with effects on gene transcription that appear to be causally related to …
Analysis of gene induction in human fibroblasts and bladder cancer cells exposed to the methylation inhibitor 5-aza-2′-deoxycytidine
Hypermethylation of the promoters of cancer-related genes is often associated with their
inactivation during tumorigenesis. Several preclinical and clinical trials have been …
inactivation during tumorigenesis. Several preclinical and clinical trials have been …
The absence of p53 is critical for the induction of apoptosis by 5-aza-2′-deoxycytidine
M Nieto, E Samper, MF Fraga, G González de Buitrago… - Oncogene, 2004 - nature.com
The absence of functional p53 has complex consequences on the cellular responses to
cytotoxic drugs. Here, we have examined the role of p53 in the response to 5-aza-2 …
cytotoxic drugs. Here, we have examined the role of p53 in the response to 5-aza-2 …
Inhibition of histone deacetylation does not block resilencing of p16 after 5-aza-2′-deoxycytidine treatment
G Egger, AM Aparicio, SG Escobar, PA Jones - Cancer research, 2007 - AACR
Epigenetic drugs are in use in clinical trials of various human cancers and are potent at
reactivating genes silenced by DNA methylation and chromatin modifications. We report …
reactivating genes silenced by DNA methylation and chromatin modifications. We report …
Long term transcriptional reactivation of epigenetically silenced genes in colorectal cancer cells requires DNA hypomethylation and histone acetylation
D Mossman, RJ Scott - PLoS One, 2011 - journals.plos.org
Epigenetic regulation of genes involves the coordination of DNA methylation and histone
modifications to maintain transcriptional status. These two features are frequently disrupted …
modifications to maintain transcriptional status. These two features are frequently disrupted …
DNA demethylation and invasive cancer: implications for therapeutics
D Cheishvili, L Boureau, M Szyf - British journal of …, 2015 - Wiley Online Library
One of the hallmarks of cancer is aberrant DNA methylation, which is associated with
abnormal gene expression. Both hypermethylation and silencing of tumour suppressor …
abnormal gene expression. Both hypermethylation and silencing of tumour suppressor …
Effect of histone deacetylase inhibitor LAQ824 on antineoplastic action of 5-Aza-2′-deoxycytidine (decitabine) on human breast carcinoma cells
A Hurtubise, RL Momparler - Cancer chemotherapy and pharmacology, 2006 - Springer
Purpose: Epigenetic silencing of tumor suppressor genes (TSGs) by aberrant DNA
methylation and chromatin deacetylation provides interesting targets for chemotherapeutic …
methylation and chromatin deacetylation provides interesting targets for chemotherapeutic …
Inhibition of DNA methylation by 5-aza-2′-deoxycytidine suppresses the growth of human tumor cell lines
CM Bender, MM Pao, PA Jones - Cancer research, 1998 - AACR
Alterations in DNA methylation patterns accompany the establishment of immortal cell lines.
De novo methylation of CpG islands within the control regions of growth-regulatory genes …
De novo methylation of CpG islands within the control regions of growth-regulatory genes …