Batch-effect detection, correction and characterisation in Illumina HumanMethylation450 and MethylationEPIC BeadChip array data
Background Genomic technologies can be subject to significant batch-effects which are
known to reduce experimental power and to potentially create false positive results. The …
known to reduce experimental power and to potentially create false positive results. The …
A coherent approach for analysis of the Illumina HumanMethylation450 BeadChip improves data quality and performance in epigenome-wide association studies
B Lehne, AW Drong, M Loh, W Zhang, WR Scott… - Genome biology, 2015 - Springer
DNA methylation plays a fundamental role in the regulation of the genome, but the optimal
strategy for analysis of genome-wide DNA methylation data remains to be determined. We …
strategy for analysis of genome-wide DNA methylation data remains to be determined. We …
RELIC: a novel dye-bias correction method for Illumina Methylation BeadChip
Abstract Background The Illumina Infinium HumanMethylation450 BeadChip and its
successor, Infinium MethylationEPIC BeadChip, have been extensively utilized in …
successor, Infinium MethylationEPIC BeadChip, have been extensively utilized in …
A consistent pattern of slide effects in Illumina DNA methylation BeadChip array data
Background: Recent studies have identified thousands of associations between DNA
methylation CpGs and complex diseases/traits, emphasizing the critical role of epigenetics …
methylation CpGs and complex diseases/traits, emphasizing the critical role of epigenetics …
RCP: a novel probe design bias correction method for Illumina Methylation BeadChip
Abstract Motivation: The Illumina HumanMethylation450 BeadChip has been extensively
utilized in epigenome-wide association studies. This array and its successor, the …
utilized in epigenome-wide association studies. This array and its successor, the …
ENmix: a novel background correction method for Illumina HumanMethylation450 BeadChip
Abstract The Illumina HumanMethylation450 BeadChip is increasingly utilized in epigenome-
wide association studies, however, this array-based measurement of DNA methylation is …
wide association studies, however, this array-based measurement of DNA methylation is …
[HTML][HTML] Identification of polymorphic and off-target probe binding sites on the Illumina Infinium MethylationEPIC BeadChip
Genome-wide analysis of DNA methylation has now become a relatively inexpensive
technique thanks to array-based methylation profiling technologies. The recently developed …
technique thanks to array-based methylation profiling technologies. The recently developed …
DNA methylation levels are highly correlated between pooled samples and averaged values when analysed using the Infinium HumanMethylation450 BeadChip …
C Gallego-Fabrega, C Carrera, E Muiño, J Montaner… - Clinical …, 2015 - Springer
Background DNA methylation is a heritable and stable epigenetic mark implicated in
complex human traits. Epigenome-wide association studies (EWAS) using array-based …
complex human traits. Epigenome-wide association studies (EWAS) using array-based …
Reliability of DNA methylation measures using Illumina methylation BeadChip
Illumina BeadChips are widely utilized in epigenome-wide association studies (EWAS).
Several studies have reported that many probes on these arrays have poor reliability. Here …
Several studies have reported that many probes on these arrays have poor reliability. Here …
Comparison of pre-processing methodologies for Illumina 450k methylation array data in familial analyses
Background Human methylome mapping in health and disease states has largely relied on
Illumina Human Methylation 450k array (450k array) technology. Accompanying this has …
Illumina Human Methylation 450k array (450k array) technology. Accompanying this has …