Sulforaphane (SFN), an isothiocyanate derived from cruciferous vegetables, induces potent
anti-proliferative effects in prostate cancer cells. One mechanism that may contribute to the …

Epigenetic changes, including aberrant DNA methylation, result in altered gene expression
and play an important role in carcinogenesis. Phytochemicals such as sulforaphane (SFN) …

BACKGROUND The clinical success of the nucleoside analogs 5‐aza‐cytidine (5‐azaC)
and 5‐aza‐2′ deoxycytidine (5‐aza‐dC) as DNA methyltransferase (DNMT) inhibitors has …

Growing evidence suggests epigenetic alteration is involved during the development and
progression of prostate cancer. Previously, we found Nrf2, a key regulator of cellular …

Sulforaphane (SFN), an isothiocyanate first isolated from broccoli, exhibits chemopreventive
properties in prostate cancer cells through mechanisms that are poorly understood. We …

Prostate cancer patients whose tumors develop resistance to conventional treatment often
turn to natural, plant-derived products, one of which is sulforaphane (SFN). This study was …

Epidemiological studies recently concluded that consumption of cruciferous vegetables such
as broccoli, cabbage, and cauliflower, etc. is inversely related to prostate cancer risk …

Scope: Sulforaphane (SFN) is an isothiocyanate derived from cruciferous vegetables such
as broccoli. The ability of SFN to inhibit histone deacetylase (HDAC) enzymes may be one …

Estrogen Receptor‐β (ER‐β), a tumor‐suppressor in prostate cancer, is epigenetically
repressed by hypermethylation of its promoter. DNA‐methyltransferases (DNMTs), which …

Scope Epidemiological studies provide evidence that consumption of cruciferous
vegetables, like broccoli, can reduce the risk of cancer development. Sulforaphane (SFN) is …