Effects of Rett syndrome mutations of the methyl-CpG binding domain of the transcriptional repressor MeCP2 on selectivity for association with methylated DNA
E Ballestar, TM Yusufzai, AP Wolffe - Biochemistry, 2000 - ACS Publications
We have investigated the properties of mutant forms of the methyl-CpG binding
transcriptional repressor MeCP2 associated with Rett syndrome, a childhood …
transcriptional repressor MeCP2 associated with Rett syndrome, a childhood …
Functional consequences of Rett syndrome mutations on human MeCP2
TM Yusufzai, AP Wolffe - Nucleic acids research, 2000 - academic.oup.com
The neurodevelopmental disorder known as Rett syndrome has recently been linked to the
methyl-CpG-binding transcriptional repressor, MeCP2. In this report we examine the …
methyl-CpG-binding transcriptional repressor, MeCP2. In this report we examine the …
A mutation-led search for novel functional domains in MeCP2
J Guy, B Alexander-Howden… - Human Molecular …, 2018 - academic.oup.com
Most missense mutations causing Rett syndrome (RTT) affect domains of MeCP2 that have
been shown to either bind methylated DNA or interact with a transcriptional co-repressor …
been shown to either bind methylated DNA or interact with a transcriptional co-repressor …
DNA methylation in the gene body influences MeCP2-mediated gene repression
B Kinde, DY Wu, ME Greenberg… - Proceedings of the …, 2016 - National Acad Sciences
Rett syndrome is a severe neurodevelopmental disorder caused by mutations in the methyl-
CpG binding protein gene (MECP2). MeCP2 is a methyl-cytosine binding protein that is …
CpG binding protein gene (MECP2). MeCP2 is a methyl-cytosine binding protein that is …
Multiple modes of interaction between the methylated DNA binding protein MeCP2 and chromatin
T Nikitina, X Shi, RP Ghosh… - … and cellular biology, 2007 - Am Soc Microbiol
Mutations of the methylated DNA binding protein MeCP2, a multifunctional protein that is
thought to transmit epigenetic information encoded as methylated CpG dinucleotides to the …
thought to transmit epigenetic information encoded as methylated CpG dinucleotides to the …
MeCP2 and other methyl‐CpG binding proteins
HF Jørgensen, A Bird - Mental retardation and developmental …, 2002 - Wiley Online Library
DNA methylation is an epigenetic modification that is implicated in transcriptional silencing.
Recently, it has become increasingly clear that both correct levels and proper interpretation …
Recently, it has become increasingly clear that both correct levels and proper interpretation …
DNA methylation and Rett syndrome
S Kriaucionis, A Bird - Human molecular genetics, 2003 - academic.oup.com
Methylation of cytosine in human DNA has been studied for over 60 years, but has only
recently been confirmed as an important player in human disease. Rett syndrome is a …
recently been confirmed as an important player in human disease. Rett syndrome is a …
[HTML][HTML] MeCP2 binding to DNA depends upon hydration at methyl-CpG
MeCP2 is an essential transcriptional repressor that mediates gene silencing through
binding to methylated DNA. Binding specificity has been thought to depend on hydrophobic …
binding to methylated DNA. Binding specificity has been thought to depend on hydrophobic …
Binding of the Rett syndrome protein, MeCP2, to methylated and unmethylated DNA and chromatin
Abstract Methylated CpG Binding Protein 2 (MeCP2) is a nuclear protein named for its ability
to selectively recognize methylated DNA. Much attention has been focused on …
to selectively recognize methylated DNA. Much attention has been focused on …
[HTML][HTML] DNA binding selectivity of MeCP2 due to a requirement for A/T sequences adjacent to methyl-CpG
RJ Klose, SA Sarraf, L Schmiedeberg, SM McDermott… - Molecular cell, 2005 - cell.com
DNA methylation is interpreted by a family of methyl-CpG binding domain (MBD) proteins
that repress transcription through recruitment of corepressors that modify chromatin. To …
that repress transcription through recruitment of corepressors that modify chromatin. To …