The protein MeCP2 mediates epigenetic regulation by binding methyl-CpG (mCpG) sites on
chromatin. MeCP2 consists of six domains of which one, the methyl binding domain (MBD) …

In humans, mutations in the X-linked MECP2 gene, are the cause of Rett syndrome (RTT), a
neurodevelopmental disorder that affects mainly girls. MeCP2 binds to methylated CpGs …

Methyl-CpG binding protein 2 (MeCP2) was first identified in 1992 as a protein that binds
specifically to methylated DNA. Mutations in the MECP2 gene were later found to be the …

In vertebrates, the biological consequences of DNA methylation are often mediated by
protein factors containing conserved methyl-CpG binding domains (MBDs). Mutations in the …

Rett syndrome is a progressive neurological disorder caused by mutations in the methyl-
DNA binding protein MeCP2. The longstanding model depicting MeCP2 as a transcriptional …

Rett syndrome (RTT) is a postnatal neurodevelopmental disorder characterized by the loss
of acquired motor and language skills, autistic features, and unusual stereotyped …

MeCP2 is a DNA binding protein that represses transcription of methylated genes in vitro,
but the endogenous function of MeCP2 in vivo is unclear. Here, we demonstrate that in …

Mutations in the X-linked gene MECP2 (methyl CpG-binding protein 2) are the primary
cause of the neurodevelopmental disorder RTT (Rett syndrome), and are also implicated in …

Rett syndrome (RTT) is a severe neurodevelopmental disorder affecting almost exclusively
girls. It is currently considered a monogenic X-linked dominant disorder due to mutations in …

Rett syndrome is a neurodevelopmental disorder with severe mental retardation caused by
mutations in the MECP2 gene. Mutations in the MECP2 gene are also associated with other …