Pathogenesis of the C3 glomerulopathies and reclassification of MPGN

AS Bomback, GB Appel - Nature Reviews Nephrology, 2012 - nature.com
Until recently, membranoproliferative glomerulonephritis (MPGN) was clinically classified as
either primary, idiopathic MPGN or as secondary MPGN when an underlying aetiology was …

[HTML][HTML] Membranoproliferative glomerulonephritis and C3 glomerulopathy: resolving the confusion

S Sethi, CM Nester, RJH Smith - Kidney international, 2012 - Elsevier
Membranoproliferative glomerulonephritis (MPGN) denotes a general pattern of glomerular
injury that is easily recognized by light microscopy. With additional studies, MPGN …

[HTML][HTML] C3 glomerulopathy: what's in a name?

VD D'Agati, AS Bomback - Kidney international, 2012 - Elsevier
Whereas early classifications of membranoproliferative glomerulonephritis (MPGN) were
based on morphologic features, the modern approach is directed at immunofluorescence …

Histopathology of MPGN and C3 glomerulopathies

HT Cook, MC Pickering - Nature Reviews Nephrology, 2015 - nature.com
Abstract'Membranoproliferative'describes glomerular injury characterized by capillary wall
thickening and mesangial expansion owing to increased matrix deposition and …

Membranoproliferative glomerulonephritis: no longer the same disease and may need very different treatment

M Noris, E Daina, G Remuzzi - Nephrology Dialysis …, 2023 - academic.oup.com
Membranoproliferative glomerulonephritis (MPGN) is a pattern of glomerular injury that may
be primary or secondary to infections, autoimmune diseases and haematological disorders …

[HTML][HTML] Toward a working definition of C3 glomerulopathy by immunofluorescence

J Hou, GS Markowitz, AS Bomback, GB Appel… - Kidney international, 2014 - Elsevier
Precise immunofluorescence criteria for C3 glomerulopathy remain to be defined. Here we
tested hierarchical immunofluorescence criteria with varying stringency for C3 …

Complement gene variants determine the risk of immunoglobulin-associated MPGN and C3 glomerulopathy and predict long-term renal outcome

P Iatropoulos, M Noris, C Mele, R Piras, E Valoti… - Molecular …, 2016 - Elsevier
Background Membranoproliferative glomerulonephritis (MPGN) is an uncommon cause of
chronic nephropathy recently reclassified into immunoglobulin-associated MPGN (Ig-MPGN) …

Practical management of C3 glomerulopathy and Ig-mediated MPGN: facts and uncertainties

F Fakhouri, M Le Quintrec, V Frémeaux-Bacchi - Kidney international, 2020 - Elsevier
In recent years, a substantial body of experimental and clinical work has been devoted to C3
glomerulopathy and Ig-mediated membranoproliferative glomerulonephritis. Despite the …

Hereditary and acquired complement dysregulation in membranoproliferative glomerulonephritis

C Licht, V Fremeaux-Bacchi - Thrombosis and haemostasis, 2009 - thieme-connect.com
Membranoproliferative glomerulonephritis (MPGN) is a chronic progressive renal disease
that is diagnosed on the basis of renal histological features. Several MPGN subtypes have …

C3 Glomerulopathy

M Riedl, P Thorner, C Licht - Pediatric Nephrology, 2017 - Springer
Recent advances in our understanding of the disease pathology of membranoproliferative
glomerulonephritis has resulted in its re-classification as complement C3 glomerulopathy …