A novel method of quantifying hemodynamic delays to improve hemodynamic response, and CVR estimates in CO2 challenge fMRI
Elevated carbon dioxide (CO2) in breathing air is widely used as a vasoactive stimulus to
assess cerebrovascular functions under hypercapnia (ie,“stress test” for the brain). Blood …
assess cerebrovascular functions under hypercapnia (ie,“stress test” for the brain). Blood …
Quantitative mapping of cerebrovascular reactivity using resting-state BOLD fMRI: validation in healthy adults
In conventional neuroimaging, cerebrovascular reactivity (CVR) is quantified primarily using
the blood-oxygenation level-dependent (BOLD) functional MRI (fMRI) signal, specifically, as …
the blood-oxygenation level-dependent (BOLD) functional MRI (fMRI) signal, specifically, as …
[HTML][HTML] Comparing end-tidal CO2, respiration volume per time (RVT), and average gray matter signal for mapping cerebrovascular reactivity amplitude and delay with …
Cerebrovascular reactivity (CVR), defined as the cerebral blood flow response to a
vasoactive stimulus, is an imaging biomarker with demonstrated utility in a range of diseases …
vasoactive stimulus, is an imaging biomarker with demonstrated utility in a range of diseases …
Mapping the end-tidal CO2 response function in the resting-state BOLD fMRI signal: Spatial specificity, test–retest reliability and effect of fMRI sampling rate
AM Golestani, C Chang, JB Kwinta, YB Khatamian… - Neuroimage, 2015 - Elsevier
The blood oxygenation level dependent (BOLD) signal measures brain function indirectly
through physiological processes and hence is susceptible to global physiological changes …
through physiological processes and hence is susceptible to global physiological changes …
Resting fluctuations in arterial carbon dioxide induce significant low frequency variations in BOLD signal
RG Wise, K Ide, MJ Poulin, I Tracey - Neuroimage, 2004 - Elsevier
Carbon dioxide is a potent cerebral vasodilator. We have identified a significant source of
low-frequency variation in blood oxygen level-dependent (BOLD) magnetic resonance …
low-frequency variation in blood oxygen level-dependent (BOLD) magnetic resonance …
Reproducibility of BOLD signal change induced by breath holding
Blood oxygen level dependent (BOLD) contrast is influenced by some physiological factors
such as blood flow and blood volume that can be a source of variability in fMRI analysis …
such as blood flow and blood volume that can be a source of variability in fMRI analysis …
[HTML][HTML] A practical modification to a resting state fMRI protocol for improved characterization of cerebrovascular function
Cerebrovascular reactivity (CVR), defined here as the Blood Oxygenation Level Dependent
(BOLD) response to a CO 2 pressure change, is a useful metric of cerebrovascular function …
(BOLD) response to a CO 2 pressure change, is a useful metric of cerebrovascular function …
Modeling of dynamic cerebrovascular reactivity to spontaneous and externally induced CO2 fluctuations in the human brain using BOLD-fMRI
PC Prokopiou, KTS Pattinson, RG Wise, GD Mitsis - Neuroimage, 2019 - Elsevier
In this work, we investigate the regional characteristics of the dynamic interactions between
arterial CO 2 and BOLD (dynamic cerebrovascular reactivity-dCVR) during normal breathing …
arterial CO 2 and BOLD (dynamic cerebrovascular reactivity-dCVR) during normal breathing …
Global cerebral oxidative metabolism during hypercapnia and hypocapnia in humans: implications for BOLD fMRI
The effect of carbon dioxide (CO2) on cerebral metabolism is of tremendous interest to
functional imaging. In particular, mild-to-moderate hypercapnia is routinely used in …
functional imaging. In particular, mild-to-moderate hypercapnia is routinely used in …
Dynamic forcing of end-tidal carbon dioxide and oxygen applied to functional magnetic resonance imaging
RG Wise, KTS Pattinson, DP Bulte… - Journal of Cerebral …, 2007 - journals.sagepub.com
Investigations into the blood oxygenation level-dependent (BOLD) functional MRI signal
have used respiratory challenges with the aim of probing cerebrovascular physiology. Such …
have used respiratory challenges with the aim of probing cerebrovascular physiology. Such …