Epigenetic mechanisms are implicated in gene regulation and the development of different
diseases. The epigenome differs between cell types and has until now only been …

Physical activity is a strong stimulus influencing the overall physiology of the human body.
Exercises lead to biochemical changes in various tissues and exert an impact on gene …

Background Environmental factors can influence obesity by epigenetic mechanisms.
Adipose tissue plays a key role in obesity-related metabolic dysfunction, and gastric bypass …

Many epigenetic association studies have attempted to identify DNA methylation markers in
blood that are able to mirror those in target tissues. Although some have suggested potential …

Aims/hypothesis Energy-dense diets that are high in fat are associated with a risk of
metabolic diseases. The underlying molecular mechanisms could involve epigenetics, as …

Background: Adiposity is a risk factor for type 2 diabetes and cardiovascular disease,
suggesting an important role for adipose tissue in the development of these conditions. The …

Genetic variants that associate with DNA methylation at CpG sites (methylation quantitative
trait loci, meQTLs) offer a potential biological mechanism of action for disease associated …

To identify epigenetic patterns, which may predispose to type 2 diabetes (T2D) due to a
family history (FH) of the disease, we analyzed DNA methylation genome-wide in skeletal …

The characterization of the epigenetic changes within the obesity-related adipose tissue will
provide new insights to understand this metabolic disorder, but adipose tissue is not easy to …

Objective/methods DNA methylation plays an important role in obesity and related metabolic
complications. We examined genome-wide DNA promoter methylation along with mRNA …