Polycystic kidney disease is an inherited disorder of parenchymal structure that leads to
renal failure. Cysts begin as focal dilations in proximal tubules and collecting ducts, giving …

The primary structure of polycystin predicts a large integral membrane protein with multiple
cell recognition motifs, but its function remains unknown. Insight into polycystin's normal …

Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the formation of
fluid‐filled cysts in both kidneys, in addition to a variety of extra‐renal manifestations. The …

Interaction of polycystin-1 (PC1) and Gα12 is important for development of kidney cysts in
autosomal dominant polycystic kidney disease (ADPKD). The integrity of cell polarity and …

Polycystic kidney disease (PKD) is a disease of the nephron, characterized by the formation
of multiple renal tubular cysts, leading to endstage renal failure. The most common form is …

Autosomal dominant polycystic kidney disease (ADPKD) is a common genetic disease that
affects both adults and children. Renal cysts are the cardinal sign of the disease that also …

Polycystin-1, the protein defective in a majority of patients with autosomal dominant
polycystic kidney disease, is a ubiquitously expressed multi-span transmembrane protein of …

Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited
human renal disease and is caused by mutations in two genes, PKD1 (85%) and PKD2 …

Abstract Mutations in polycystin-1 (PC-1) are responsible for autosomal dominant polycystic
kidney disease (ADPKD), characterized by formation of fluid-filled tubular cysts. The PC-1 is …

Abstract Dysregulation of polycystin-1 (PC1) leads to autosomal dominant polycystic kidney
disease (ADPKD), a disorder characterized by the formation of multiple bilateral renal cysts …