Autosomal recessive polycystic kidney disease is caused by mutations in PKHD1, which
encodes the membrane-associated receptor-like protein fibrocystin/polyductin (FPC). FPC …

PKD2, the second gene for the autosomal dominant polycystic kidney disease (ADPKD),
encodes a protein, polycystin-2, with predicted structural similarity to cation channel …

In individuals with autosomal dominant polycystic kidney disease (ADPKD), renal function
deteriorates as the kidneys become replaced by multitudes of fluid-filled cysts. Although the …

PKD1, the major gene mutated in autosomal dominant polycystic kidney disease, was
identified in 1994, and fully sequenced in 1995. The protein which it encodes, polycystin-1 …

The PKD1-encoded protein,“polycystin-1”, has a large N-terminal extracellular portion,
multiple transmembrane domains, and a short intracellular C-terminal tail with four tyrosine …

Autosomal-dominant polycystic kidney disease (ADPKD) is a common hereditary disease
that features multiple cystogenesis in various organs and vascular defects. The genes …

It is 20 years since the identification of PKD1, the major gene mutated in autosomal
dominant polycystic kidney disease (ADPKD), followed closely by the cloning of PKD2 …

The Pkd2 gene encodes an integral protein (~ 130 kDa), named polycystin-2 (PC-2). PC-2 is
mainly involved in autosomal dominant polycystic kidney disease. Recently, polycystin …

PKD1 is the major locus of the common genetic disorder autosomal dominant polycystic
kidney disease (ADPKD). Analysis of the predicted protein sequence of the human PKD1 …

The root cause for most cases of autosomal-dominant polycystic kidney disease (ADPKD) is
mutations in the polycystin-1 (PC1) gene. While PC1 has been implicated in a perplexing …