[HTML][HTML] The dynamics of DNA methylation covariation patterns in carcinogenesis
Recently it has been observed that cancer tissue is characterised by an increased variability
in DNA methylation patterns. However, how the correlative patterns in genome-wide DNA …
in DNA methylation patterns. However, how the correlative patterns in genome-wide DNA …
Identification of driver and passenger DNA methylation in cancer by epigenomic analysis
S Kalari, GP Pfeifer - Advances in genetics, 2010 - Elsevier
Human cancer genomes are characterized by widespread aberrations in DNA methylation
patterns including DNA hypomethylation of mostly repetitive sequences and …
patterns including DNA hypomethylation of mostly repetitive sequences and …
[HTML][HTML] Corruption of the intra-gene DNA methylation architecture is a hallmark of cancer
Epigenetic processes-including DNA methylation-are increasingly seen as having a
fundamental role in chronic diseases like cancer. It is well known that methylation levels at …
fundamental role in chronic diseases like cancer. It is well known that methylation levels at …
[HTML][HTML] Tissue-independent and tissue-specific patterns of DNA methylation alteration in cancer
Background There is growing evidence that DNA methylation alterations contribute to
carcinogenesis. While cancer tissue exhibits widespread DNA methylation changes, the …
carcinogenesis. While cancer tissue exhibits widespread DNA methylation changes, the …
Genome-wide distribution of DNA methylation and DNA demethylation and related chromatin regulators in cancer
DNA methylation plays an important role in the regulation of gene expression, as it is the first
epigenetic modification to take place on a given DNA strand. Several factors may directly or …
epigenetic modification to take place on a given DNA strand. Several factors may directly or …
[HTML][HTML] Hidden among the crowd: differential DNA methylation-expression correlations in cancer occur at important oncogenic pathways
A Mosquera Orgueira - Frontiers in Genetics, 2015 - frontiersin.org
DNA methylation is a frequent epigenetic mechanism that participates in transcriptional
repression. Variations in DNA methylation with respect to gene expression are constant …
repression. Variations in DNA methylation with respect to gene expression are constant …
Differential variability improves the identification of cancer risk markers in DNA methylation studies profiling precursor cancer lesions
AE Teschendorff, M Widschwendter - Bioinformatics, 2012 - academic.oup.com
Motivation: The standard paradigm in omic disciplines has been to identify biologically
relevant biomarkers using statistics that reflect differences in mean levels of a molecular …
relevant biomarkers using statistics that reflect differences in mean levels of a molecular …
[HTML][HTML] The dynamics and prognostic potential of DNA methylation changes at stem cell gene loci in women's cancer
J Zhuang, A Jones, SH Lee, E Ng, H Fiegl… - PLoS …, 2012 - journals.plos.org
Aberrant DNA methylation is an important cancer hallmark, yet the dynamics of DNA
methylation changes in human carcinogenesis remain largely unexplored. Moreover, the …
methylation changes in human carcinogenesis remain largely unexplored. Moreover, the …
Comparative DNA methylation analysis to decipher common and cell type-specific patterns among multiple cell types
DNA methylation has been proved to play important roles in cell development and complex
diseases through comparative studies of DNA methylation profiles across different tissues …
diseases through comparative studies of DNA methylation profiles across different tissues …
[HTML][HTML] Pan-cancer analysis of frequent DNA co-methylation patterns reveals consistent epigenetic landscape changes in multiple cancers
Background DNA methylation is the major form of epigenetic modifications through which
the cell regulates the gene expression and silencing. There have been extensive studies on …
the cell regulates the gene expression and silencing. There have been extensive studies on …