There is an association between depression and chronic pain, and some antidepressants
exert antinociceptive effects in humans and laboratory animals. We examined the effects of …

Fenfluramine is an indirect agonist of 5-hydroxytryptamine (5-HT) receptors that acts by
evoking 5-HT release and blocking 5-HT reuptake in neuronal cells. The current study …

Background Tricyclic antidepressants relieve neuropathic pain, and the analgesic properties
of tricyclic antidepressants are substantiated in human experimental pain models. It has …

Background Nerve injury promotes release of 5-HT at the spinal cord. Once released, 5-HT
may produce antinociceptive or pronociceptive effects depending of the nature of 5-HT …

Antidepressants are one of the first line treatments for neuropathic pain but their use is
limited by the incidence and severity of side effects of tricyclics and the weak effectiveness of …

The role of 5-HT receptors in fluoxetine-induced nociception and antinociception in rats was
assessed. Formalin produced a typical pattern of flinching and licking/lifting behaviors. Local …

Abstract Serotonin (5-HT) participates in pain modulation by interacting with different 5-HT
receptors. The role of 5-HT 5A receptor in neuropathic pain has not previously studied. The …

Peripheral branches of the trigeminal nerve may be damaged during maxillofacial injury or
surgical procedures and trigeminal trauma may induce severe pain that is very challenging …

To examine the role of the descending serotonergic system in the regulation of spinal
nociceptive processing, the effects of serotonin (5-HT) and selective ligands for 5-HT …

The antinociceptive role of spinal 5-HT 5A receptors in rat models of pain along with their
expression was evaluated in the spinal cord and dorsal root ganglion (DRG). Nociception …