DNA methylation (5-methylcytosine, 5mC) is a major form of DNA modification in the
mammalian genome that plays critical roles in chromatin structure and gene expression. In …

Methylation of DNA is an essential epigenetic control mechanism in mammals. During
embryonic development, cells are directed toward their future lineages, and DNA …

Cell type-specific DNA methylation patterns are established during mammalian
development and maintained in adult somatic cells. Understanding how these patterns of 5 …

DNA methylation is a fundamentally important epigenetic modification of the mammalian
genome that has widespread influences on gene expression. During germ-cell specification …

Abstract In mammals, DNA 5-hydroxymethylcytosine (5hmC) is involved in methylation
reprogramming during early embryonic development. Yet, to what extent 5hmC participates …

Background DNA methylomes are extensively reprogrammed during mouse pre-
implantation and early germ cell development. The main feature of this reprogramming is a …

Abstract Development from separate parental germ cells through fertilization and
proceeding to a fully functioning adult animal occurs through an intricate program of …

DNA methylation is of paramount importance for mammalian embryonic development. DNA
methylation has numerous functions: it is implicated in the repression of transposons and …

DNA methylation is essential for the control of a number of biological mechanisms in
mammals [1]. Mammalian development is accompanied by two major waves of genome …

DNA methylation occurs at cytosines, predominantly in the CpG dinucleotide context and is
a key epigenetic regulator of embryogenesis and stem-cell differentiation in mammals. The …