Background Genomic methylation patterns are established during gametogenesis, and
perpetuated in somatic cells by faithful maintenance methylation. There have been previous …

DNA methylation is one of a number of modes of epigenetic gene regulation. Here, we
profile the DNA methylome, transcriptome, and global occupancy of histone modifications …

Dynamic epigenetic reprogramming occurs during mammalian germ cell development,
although the targets of this process, including DNA demethylation and de novo methylation …

Publisher Summary This chapter discusses the deoxyribonucleic acid (DNA) methylation
from embryo to adult. The existence of tissue-specific methylation patterns and the results of …

Epigenetic reprogramming of parental genomes following fertilization is important to ensure
compatibility for totipotency and development thereafter. New studies by Jiang et al. and …

The acquisition of genomic methylation in the male germ line is initiated prenatally in diploid
gonocytes, while DNA methylation in the female germ line is initiated postnatally in growing …

DNA methylation is one of the most extensively studied epigenetic marks. It is involved in
transcriptional gene silencing and plays important roles during mammalian development. Its …

DNA methylation is a crucial epigenetic modification of the genome that is involved in
regulating many cellular processes. These include embryonic development, transcription …

The levels of genomic DNA methylation in vertebrate species display a wide range of
developmental dynamics. Here, we show that in contrast to mice, the paternal genome of the …

Abstract Development in mammals is accompanied by specific de novo and demethylation
events that are thought to stabilize differentiated cell phenotypes. We demonstrate that a …