Developmentally linked human DNA hypermethylation is associated with down-modulation, repression, and upregulation of transcription
ABSTRACT DNA methylation can affect tissue-specific gene transcription in ways that are
difficult to discern from studies focused on genome-wide analyses of differentially …
difficult to discern from studies focused on genome-wide analyses of differentially …
Cross-tissue patterns of DNA hypomethylation reveal genetically distinct histories of cell development
Background Establishment of DNA methylation (DNAme) patterns is essential for balanced
multi-lineage cellular differentiation, but exactly how these patterns drive cellular …
multi-lineage cellular differentiation, but exactly how these patterns drive cellular …
Characterization of tissue-specific differential DNA methylation suggests distinct modes of positive and negative gene expression regulation
Background DNA methylation plays an important role in regulating gene expression during
many biological processes. However, the mechanism of DNA-methylation-dependent gene …
many biological processes. However, the mechanism of DNA-methylation-dependent gene …
Association of 5-hydroxymethylation and 5-methylation of DNA cytosine with tissue-specific gene expression
Differentially methylated or hydroxymethylated regions (DMRs) in mammalian DNA are often
associated with tissue-specific gene expression but the functional relationships are still …
associated with tissue-specific gene expression but the functional relationships are still …
Tissue-specific DNA methylation is conserved across human, mouse, and rat, and driven by primary sequence conservation
Background Uncovering mechanisms of epigenome evolution is an essential step towards
understanding the evolution of different cellular phenotypes. While studies have confirmed …
understanding the evolution of different cellular phenotypes. While studies have confirmed …
DNA demethylation pathways: recent insights
C Li - Genetics & Epigenetics, 2013 - journals.sagepub.com
DNA methylation is a major epigenetic regulatory mechanism for gene expression and cell
differentiation. Until recently, it was still unclear how unmethylated regions in mammalian …
differentiation. Until recently, it was still unclear how unmethylated regions in mammalian …
DNA methylation and differentiation: silencing, upregulation and modulation of gene expression
Differentiation-related DNA methylation is receiving increasing attention, partly owing to
new, whole-genome analyses. These revealed that cell type-specific differential methylation …
new, whole-genome analyses. These revealed that cell type-specific differential methylation …
Longitudinal genome-wide DNA methylation analysis uncovers persistent early-life DNA methylation changes
RF Pérez, P Santamarina, JR Tejedor… - Journal of translational …, 2019 - Springer
Background Early life is a period of drastic epigenetic remodeling in which the epigenome is
especially sensitive to extrinsic and intrinsic influence. However, the epigenome-wide …
especially sensitive to extrinsic and intrinsic influence. However, the epigenome-wide …
Genome-wide survey reveals dynamic widespread tissue-specific changes in DNA methylation during development
Background Changes in DNA methylation in the mammalian genome during development
are frequent events and play major roles regulating gene expression and other …
are frequent events and play major roles regulating gene expression and other …
Epigenetics: differential DNA methylation in mammalian somatic tissues
H Nagase, S Ghosh - The FEBS journal, 2008 - Wiley Online Library
Epigenetics refers to heritable phenotypic alterations in the absence of DNA sequence
changes, and DNA methylation is one of the extensively studied epigenetic alterations. DNA …
changes, and DNA methylation is one of the extensively studied epigenetic alterations. DNA …