It's not all about us: evolution and maintenance of Cryptococcus virulence requires selection outside the human host
AC Gerstein, K Nielsen - Yeast, 2017 - Wiley Online Library
Cryptococcus is predominantly an AIDS‐related pathogen that causes significant morbidity
and mortality in immunocompromised patients. Research studies have historically focused …
and mortality in immunocompromised patients. Research studies have historically focused …
Congenic strains for genetic analysis of virulence traits in Cryptococcus gattii
Cryptococcus gattii is responsible for a large outbreak of potentially fatal disease that started
in the late 1990s on Vancouver Island, Canada. How this fungus and the outbreak isolates …
in the late 1990s on Vancouver Island, Canada. How this fungus and the outbreak isolates …
Comparative Genomics of Serial Isolates of Cryptococcus neoformans Reveals Gene Associated With Carbon Utilization and Virulence
KL Ormerod, CA Morrow, EWL Chow… - G3: Genes …, 2013 - academic.oup.com
The opportunistic fungal pathogen Cryptococcus neoformans is a leading cause of mortality
among the human immunodeficiency virus/acquired immunodeficiency syndrome …
among the human immunodeficiency virus/acquired immunodeficiency syndrome …
Profiling a killer, the development of Cryptococcus neoformans
L Kozubowski, J Heitman - FEMS microbiology reviews, 2012 - academic.oup.com
The ability of fungi to transition between unicellular and multicellular growth has a profound
impact on our health and the economy. Many important fungal pathogens of humans …
impact on our health and the economy. Many important fungal pathogens of humans …
Advances in Cryptococcus genomics: insights into the evolution of pathogenesis
Cryptococcus species are the causative agents of cryptococcal meningitis, a significant
source of mortality in immunocompromised individuals. Initial work on the molecular …
source of mortality in immunocompromised individuals. Initial work on the molecular …
Expanding fungal pathogenesis: Cryptococcus breaks out of the opportunistic box
JW Kronstad, R Attarian, B Cadieux, J Choi… - Nature reviews …, 2011 - nature.com
Cryptococcus neoformans is generally considered to be an opportunistic fungal pathogen
because of its tendency to infect immunocompromised individuals, particularly those …
because of its tendency to infect immunocompromised individuals, particularly those …
[PDF][PDF] Beyond the big three: systematic analysis of virulence factors in Cryptococcus neoformans
J Kronstad, WH Jung, G Hu - Cell Host & Microbe, 2008 - cell.com
The fungal pathogen Cryptococcus neoformans has three major virulence factors: growth at
37° C, capsule synthesis, and melanin formation. Recently in Cell, Liu et al.(2008) employed …
37° C, capsule synthesis, and melanin formation. Recently in Cell, Liu et al.(2008) employed …
Cryptococcus: from environmental saprophyte to global pathogen
Cryptococcosis is a globally distributed invasive fungal infection that is caused by species
within the genus Cryptococcus which presents substantial therapeutic challenges. Although …
within the genus Cryptococcus which presents substantial therapeutic challenges. Although …
Microevolutionary traits and comparative population genomics of the emerging pathogenic fungus Cryptococcus gattii
Emerging fungal pathogens cause an expanding burden of disease across the animal
kingdom, including a rise in morbidity and mortality in humans. Yet, we currently have only a …
kingdom, including a rise in morbidity and mortality in humans. Yet, we currently have only a …
Genomic variation across a clinical Cryptococcus population linked to disease outcome
P Sephton-Clark, JL Tenor, DL Toffaletti, N Meyers… - Mbio, 2022 - Am Soc Microbiol
Cryptococcus neoformans is the causative agent of cryptococcosis, a disease with poor
patient outcomes that accounts for approximately 180,000 deaths each year. Patient …
patient outcomes that accounts for approximately 180,000 deaths each year. Patient …
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