It's not all about us: evolution and maintenance of Cryptococcus virulence requires selection outside the human host

AC Gerstein, K Nielsen - Yeast, 2017 - Wiley Online Library
Cryptococcus is predominantly an AIDS‐related pathogen that causes significant morbidity
and mortality in immunocompromised patients. Research studies have historically focused …

Congenic strains for genetic analysis of virulence traits in Cryptococcus gattii

P Zhu, B Zhai, X Lin, A Idnurm - Infection and immunity, 2013 - Am Soc Microbiol
Cryptococcus gattii is responsible for a large outbreak of potentially fatal disease that started
in the late 1990s on Vancouver Island, Canada. How this fungus and the outbreak isolates …

Comparative Genomics of Serial Isolates of Cryptococcus neoformans Reveals Gene Associated With Carbon Utilization and Virulence

KL Ormerod, CA Morrow, EWL Chow… - G3: Genes …, 2013 - academic.oup.com
The opportunistic fungal pathogen Cryptococcus neoformans is a leading cause of mortality
among the human immunodeficiency virus/acquired immunodeficiency syndrome …

Profiling a killer, the development of Cryptococcus neoformans

L Kozubowski, J Heitman - FEMS microbiology reviews, 2012 - academic.oup.com
The ability of fungi to transition between unicellular and multicellular growth has a profound
impact on our health and the economy. Many important fungal pathogens of humans …

Advances in Cryptococcus genomics: insights into the evolution of pathogenesis

CA Cuomo, J Rhodes, CA Desjardins - Memórias do Instituto …, 2018 - SciELO Brasil
Cryptococcus species are the causative agents of cryptococcal meningitis, a significant
source of mortality in immunocompromised individuals. Initial work on the molecular …

Expanding fungal pathogenesis: Cryptococcus breaks out of the opportunistic box

JW Kronstad, R Attarian, B Cadieux, J Choi… - Nature reviews …, 2011 - nature.com
Cryptococcus neoformans is generally considered to be an opportunistic fungal pathogen
because of its tendency to infect immunocompromised individuals, particularly those …

[PDF][PDF] Beyond the big three: systematic analysis of virulence factors in Cryptococcus neoformans

J Kronstad, WH Jung, G Hu - Cell Host & Microbe, 2008 - cell.com
The fungal pathogen Cryptococcus neoformans has three major virulence factors: growth at
37° C, capsule synthesis, and melanin formation. Recently in Cell, Liu et al.(2008) employed …

Cryptococcus: from environmental saprophyte to global pathogen

RC May, NRH Stone, DL Wiesner, T Bicanic… - Nature Reviews …, 2016 - nature.com
Cryptococcosis is a globally distributed invasive fungal infection that is caused by species
within the genus Cryptococcus which presents substantial therapeutic challenges. Although …

Microevolutionary traits and comparative population genomics of the emerging pathogenic fungus Cryptococcus gattii

RA Farrer, K Voelz, DA Henk… - … of the Royal …, 2016 - royalsocietypublishing.org
Emerging fungal pathogens cause an expanding burden of disease across the animal
kingdom, including a rise in morbidity and mortality in humans. Yet, we currently have only a …

Genomic variation across a clinical Cryptococcus population linked to disease outcome

P Sephton-Clark, JL Tenor, DL Toffaletti, N Meyers… - Mbio, 2022 - Am Soc Microbiol
Cryptococcus neoformans is the causative agent of cryptococcosis, a disease with poor
patient outcomes that accounts for approximately 180,000 deaths each year. Patient …