Background: Assay of methylated DNA markers in stool is a promising approach for
colorectal cancer (CRC) screening. A method to capture hypermethylated CpG islands from …

Background Previous studies showed that the assessment of promoter hypermethylation of
a limited number of genes in tumor biopsies may identify the majority of colorectal tumors …

Background Stool-based molecular tests hold large potential for improving colorectal cancer
screening. Here, we investigated the analytical sensitivity of a DNA methylation assay on …

Purpose Methylated cell-free DNA in liquid biopsies are promising non-invasive biomarkers
for colorectal cancer (CRC). Optimal markers would have high sensitivity and specificity for …

Background Specific genes are methylated with high frequency in colorectal neoplasia, and
may leak into blood. Detection of multiple methylated DNA biomarkers in blood may improve …

Background The development of colorectal cancer (CRC) is accompanied by extensive
epigenetic changes, including frequent regional hypermethylation particularly of gene …

OBJECTIVES While promoter hypermethylation is a common molecular alteration of human
colorectal cancer that could be detected in the bloodstream, we tested the feasibility of …

Detection of colorectal cancer at an early stage may significantly decrease mortality from the
disease. The current screening test of colonoscopy is of high efficacy, but its acceptance in …

Aberrant DNA methylation could potentially serve as a biomarker for colorectal neoplasms.
In this study, we assessed the feasibility of using DNA methylation detected in bowel lavage …

Aberrant DNA methylation is frequently detected in gastrointestinal tumors, and can
therefore potentially be used to screen, diagnose, prognosticate, and predict colorectal …