We have validated differences in DNA methylation levels of candidate genes previously
reported to discriminate between normal colon mucosa of patients with colon cancer and …

Colorectal carcinoma (CRC) is a common cause of morbidity and mortality worldwide. Two
pathogenic pathways are involved in the development of adenoma to CRC. The first …

Hypermethylation of cytosine residues in the CpG islands of tumor suppressor genes is a
key mechanism of colorectal carcinogenesis. Detection and quantification of CpG island …

Background: Sensitive, specific blood-based tests are difficult to develop unless steps are
taken to maximize performance characteristics at every stage of marker discovery and …

Colorectal cancer (CRC) is the third most common cancer worldwide. Screening programs
allow early diagnosis and have improved the clinical management of this disease. Aberrant …

Background Identifying molecular differences between primary and metastatic colorectal
cancers—now possible with the aid of omics technologies—can improve our understanding …

Aberrant DNA methylation is a common epigenetic alteration involved in colorectal cancer
(CRC). In our previous study, we performed methylated DNA immunoprecipitation‐on‐chip …

Colorectal cancer (CRC) is the third most common cause of cancer-related death in the
United States. Early identification and treatment of pre-cancerous colorectal lesions, or node …

Colorectal cancer is the fourth most common cancer worldwide (1). There has been intense
interest in the search for potential tumor markers that can be used in the screening of …

In peripheral blood, cell-free methylated DNA has been reported to be a useful biomarker of
noninvasive blood screening for the detection of colorectal cancer (CRC), including the …