BACKGROUND Detection of fecal DNA is a promising approach to colorectal cancer
screening. However, the sensitivity of current fecal DNA tests for colorectal polyps is low. We …

Colorectal cancer (CRC) develops through the accumulation of both genetic and epigenetic
alterations. However, while the former are already used as prognostic and predictive …

Although methylated TWIST1 is a biomarker of colorectal neoplasia, its detection from serum
samples is very difficult by conventional bisulfite-based methylation assays. Therefore, we …

Background Noninvasive diagnostic markers that are capable of distinguishing patients with
colorectal cancer (CRC) from healthy individuals or patients with other cancer types are …

Colorectal cancer is the third most common cancer and a major cause of cancer-related
mortality. The lifetime risk to develop colorectal cancer is 6% in the Western world, and one …

DNA methylation, the modification of a cytosine nucleotide immediately preceding a guanine
base in a stretch of DNA, is rapidly gaining strength in the diagnostic field as a powerful tool …

Background Because of poor compliance or low sensitivity, existing diagnostic approaches
are unable to provide an efficient diagnosis of patients with gastric and colorectal cancer …

Colorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide in 2020.
Colonoscopy and the fecal immunochemical test (FIT) are commonly used as CRC …

Background: An increasing number of hypermethylated genes in stool samples have been
reported as biomarkers for the detection of colorectal cancer (CRC) or adenomas. We aimed …

Aberrant methylation of DNA has been shown to play an important role in a variety of human
cancers, developmental disorders and aging. Hence, aberrant methylation patterns in genes …