Novel Candidate Colorectal Cancer Biomarkers Identified by Methylation Microarray-Based
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Dear Sir: We found the article by Mori et al 1 recently published in GASTROENTEROLOGY
of great interest. In this paper, several novel promoter methylation target genes were …

Colorectal cancer (CRC) is a multifactorial and multistage process that occurs due to both
genetic and epigenetic variations in normal epithelial cells. Analysis of the CRC epigenome …

Background We performed a genome-wide scan of 27,578 CpG loci covering 14,475 genes
to identify differentially methylated loci (DML) in colorectal carcinoma (CRC). Methods We …

Background DNA methylation is a potential tumor marker for several cancers, including
colorectal cancer (CRC), because of its heritable and stable characteristics. Methods Using …

Aberrant DNA methylation has shown promise as a biomarker for the early detection of
cancer. To discover novel genes frequently methylated at an early stage in colorectal cancer …

Background Colorectal cancer is the fourth cause of cancer-related deaths worldwide,
though detection at early stages associates with good prognosis. Thus, there is a clear …

Background: A number of plasma methylated DNA biomarkers related to colorectal cancer
(CRC) have been identified. However, the effect of methylation level in leukocytes on …

CpG island methylation in the promoter regions of tumor suppressor genes has been shown
to occur in normal colonic tissue and can distinguish between subjects with and without …

Abstract Changes in DNA methylation, whether hypo‐or hypermethylation, have been
shown to be associated with the progression of colorectal cancer. Methylation changes …