High-resolution relaxometry-based calibrated fMRI in murine brain: Metabolic differences between awake and anesthetized states

M Xu, B Bo, M Pei, Y Chen, CY Shu… - Journal of Cerebral …, 2022 - journals.sagepub.com
Functional magnetic resonance imaging (fMRI) techniques using the blood-oxygen level-
dependent (BOLD) signal have shown great potential as clinical biomarkers of disease …

Mapping oxidative metabolism in the human brain with calibrated fMRI in health and disease

JJ Chen, B Uthayakumar… - Journal of Cerebral Blood …, 2022 - journals.sagepub.com
Conventional functional MRI (fMRI) with blood-oxygenation level dependent (BOLD)
contrast is an important tool for mapping human brain activity non-invasively. Recent interest …

Measurement of OEF and absolute CMRO2: MRI-based methods using interleaved and combined hypercapnia and hyperoxia

RG Wise, AD Harris, AJ Stone, K Murphy - Neuroimage, 2013 - Elsevier
Blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI)
is most commonly used in a semi-quantitative manner to infer changes in brain activity …

Brain region and activity-dependent properties of M for calibrated fMRI

CY Shu, P Herman, D Coman, BG Sanganahalli… - Neuroimage, 2016 - Elsevier
Calibrated fMRI extracts changes in oxidative energy demanded by neural activity based on
hemodynamic and metabolic dependencies of the blood oxygenation level-dependent …

Biophysical and physiological origins of blood oxygenation level-dependent fMRI signals

SG Kim, S Ogawa - Journal of Cerebral Blood Flow & …, 2012 - journals.sagepub.com
After its discovery in 1990, blood oxygenation level-dependent (BOLD) contrast in functional
magnetic resonance imaging (fMRI) has been widely used to map brain activation in …

Calibrated functional MRI: mapping the dynamics of oxidative metabolism

TL Davis, KK Kwong, RM Weisskoff… - Proceedings of the …, 1998 - National Acad Sciences
MRI was extended to the measurement of changes in oxidative metabolism in the normal
human during functionally induced changes in cellular activity. A noninvasive MRI method …

Calibrated fMRI for mapping absolute CMRO2: Practicalities and prospects

M Germuska, RG Wise - Neuroimage, 2019 - Elsevier
Functional magnetic resonance imaging (fMRI) is an essential workhorse of modern
neuroscience, providing valuable insight into the functional organisation of the brain. The …

Quantitative β mapping for calibrated fMRI

CY Shu, BG Sanganahalli, D Coman, P Herman… - Neuroimage, 2016 - Elsevier
The metabolic and hemodynamic dependencies of the blood oxygenation level-dependent
(BOLD) signal form the basis for calibrated fMRI, where the focus is on oxidative energy …

Calibrated fMRI

RD Hoge - Neuroimage, 2012 - Elsevier
Functional magnetic resonance imaging with blood oxygenation level-dependent (BOLD)
contrast has had a tremendous influence on human neuroscience in the last twenty years …

Global cerebral oxidative metabolism during hypercapnia and hypocapnia in humans: implications for BOLD fMRI

JJ Chen, GB Pike - Journal of Cerebral Blood Flow & …, 2010 - journals.sagepub.com
The effect of carbon dioxide (CO2) on cerebral metabolism is of tremendous interest to
functional imaging. In particular, mild-to-moderate hypercapnia is routinely used in …