DNA modification, methylation of cytosine (5mC), and oxidation of 5mC to 5-
hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) can …

In mammals, DNA methylation in the form of 5-methylcytosine (5mC) can be actively
reversed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to …

DNA methylation at cytosines (5mC) is a major epigenetic modification involved in the
regulation of multiple biological processes in mammals. How methylation is reversed was …

Methylation of cytosines in the mammalian genome represents a key epigenetic modification
and is dynamically regulated during development. Compelling evidence now suggests that …

The TET family of dioxygenases (TET1/2/3) can convert 5-methylcytosine (5mC) into 5-
hydroxymethylcytosine (5hmC) and has been shown to be involved in active and passive …

Cytosine methylation is the major epigenetic modification of metazoan DNA. Although there
is strong evidence that active DNA demethylation occurs in animal cells, the molecular …

Methylation of cytosines is a major epigenetic modification in mammalian genomes. The
levels and patterns of DNA methylation are the results of the opposing actions of methylating …

The importance of eukaryotic DNA methylation [5-methylcytosine (5mC)] in transcriptional
regulation and development was first suggested almost 40 years ago. However, the …

Epigenetic modifications of the genome play important roles in controlling gene transcription
thus regulating several molecular and cellular processes. A novel epigenetic modification–5 …

In mammals, cytosine methylation (5mC) is widely distributed throughout the genome but is
notably depleted from active promoters and enhancers. While the role of DNA methylation in …