Oxidative DNA demethylation mediated by Tet enzymes
GL Xu, J Wong - National Science Review, 2015 - academic.oup.com
DNA modification, methylation of cytosine (5mC), and oxidation of 5mC to 5-
hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) can …
hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) can …
TET-mediated active DNA demethylation: mechanism, function and beyond
In mammals, DNA methylation in the form of 5-methylcytosine (5mC) can be actively
reversed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to …
reversed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to …
[HTML][HTML] Enzymatic DNA oxidation: mechanisms and biological significance
DNA methylation at cytosines (5mC) is a major epigenetic modification involved in the
regulation of multiple biological processes in mammals. How methylation is reversed was …
regulation of multiple biological processes in mammals. How methylation is reversed was …
[HTML][HTML] Reversing DNA methylation: mechanisms, genomics, and biological functions
Methylation of cytosines in the mammalian genome represents a key epigenetic modification
and is dynamically regulated during development. Compelling evidence now suggests that …
and is dynamically regulated during development. Compelling evidence now suggests that …
Altering TET dioxygenase levels within physiological range affects DNA methylation dynamics of HEK293 cells
C Grosser, N Wagner, K Grothaus, B Horsthemke - Epigenetics, 2015 - Taylor & Francis
The TET family of dioxygenases (TET1/2/3) can convert 5-methylcytosine (5mC) into 5-
hydroxymethylcytosine (5hmC) and has been shown to be involved in active and passive …
hydroxymethylcytosine (5hmC) and has been shown to be involved in active and passive …
Emerging roles of TET proteins and 5-hydroxymethylcytosines in active DNA demethylation and beyond
Cytosine methylation is the major epigenetic modification of metazoan DNA. Although there
is strong evidence that active DNA demethylation occurs in animal cells, the molecular …
is strong evidence that active DNA demethylation occurs in animal cells, the molecular …
Tet family of 5-methylcytosine dioxygenases in mammalian development
H Zhao, T Chen - Journal of human genetics, 2013 - nature.com
Methylation of cytosines is a major epigenetic modification in mammalian genomes. The
levels and patterns of DNA methylation are the results of the opposing actions of methylating …
levels and patterns of DNA methylation are the results of the opposing actions of methylating …
Mechanism and function of oxidative reversal of DNA and RNA methylation
The importance of eukaryotic DNA methylation [5-methylcytosine (5mC)] in transcriptional
regulation and development was first suggested almost 40 years ago. However, the …
regulation and development was first suggested almost 40 years ago. However, the …
[HTML][HTML] TET enzymes and DNA hydroxymethylation in neural development and function—how critical are they?
Epigenetic modifications of the genome play important roles in controlling gene transcription
thus regulating several molecular and cellular processes. A novel epigenetic modification–5 …
thus regulating several molecular and cellular processes. A novel epigenetic modification–5 …
5mC oxidation by Tet2 modulates enhancer activity and timing of transcriptome reprogramming during differentiation
In mammals, cytosine methylation (5mC) is widely distributed throughout the genome but is
notably depleted from active promoters and enhancers. While the role of DNA methylation in …
notably depleted from active promoters and enhancers. While the role of DNA methylation in …