The Prp8 intein is one of the most widespread eukaryotic inteins, present in important
pathogenic fungi, including Cryptococcus and Aspergillus species. Because the processed …

Self-splicing proteins, called inteins, are present in many human pathogens, including the
emerging fungal threats Cryptococcus neoformans (Cne) and Cryptococcus gattii (Cga), the …

Inteins are self-splicing intervening sequences in proteins, and inteins of pathogenic
organisms can be attractive drug targets. Here, we report an intein in important fungal …

Drug resistance is a significant concern in the treatment of diseases, including
cryptococcosis caused by Cryptococcus neoformans (Cne) and Cryptococcus gattii (Cga) …

We have used comparative sequence analysis to identify an intein‐like sequence (protein
splicing element) present in Cryptococcus neoformans, a fungal pathogen of humans. The …

Inteins, self-splicing protein elements, interrupt genes and proteins in many microbes,
including the human pathogen Mycobacterium tuberculosis. Using conserved catalytic …

Mycobacterium tuberculosis harbors three protein splicing elements, called inteins, in critical
genes and their protein products. Post-translational removal of the inteins occurs …

Background We recently described a mini-intein in the PRP8 gene of a strain of the
basidiomycete Cryptococcus neoformans, an important fungal pathogen of humans. This …

Only two nuclear encoded inteins have been described. The first, SceVMA, was found in a
vacuolar ATPase gene of Saccharomyces cerevisiae and related yeasts. The second …

Multidrug-resistant pathogens are of significant concern in recent years. Hence new
antifungal and anti-bacterial drug targets are urgently needed before the situation goes …