DNA methylation plays an important role in the regulation of gene expression during
development. Methyl moieties at CpG residues suppress transcription by affecting DNA …

DNA methylation plays a role in the repression of gene expression in animal cells. In the
mouse preimplantation embryo, most genes are unmethylated but a wave of de novo …

Cytosine methylation in mammals is an epigenetic modification required for viability of the
developing embryo. It has been suggested that DNA methylation plays important roles in X …

Methylation of DNA at position five of the cytosine ring occurs at most CpG dinucleotides in
the mammalian genome and is essential for embryonic viability. With several of the key …

Epigenetic modification of the cytosine base of DNA by its methylation introduced the
possibility that beyond the inherent information contained within the nucleotide sequence …

Over three decades ago DNA methylation had been suggested to play a role in the
regulation of gene expression. This chapter reviews the development of this field of research …

The methylation of CpG islands is often equated with transcriptional inactivity and there is
overwhelming evidence that this is the case for islands located in gene promoters. Such …

DNA methylation is an epigenetic modification that is generally associated with repression of
transcription initiation at CpG-island promoters. Here we argue that, on the basis of recent …

A long path, initiated more than 40 years ago, has led to a deeper understanding of the
complexity of gene regulation in eukaryotic genomes. In addition to genetic mechanisms, the …

DNA methyltransferase is needed for normal development, perhaps because DNA
methylation plays a part in the control of gene activity. It is clear that the methylation of …