DNA methylation is a key epigenetic mechanism, needed for proper control over the
expression of genetic information and silencing of repetitive elements. Exposure to ionizing …

DNA methylation is an epigenetic mechanism that drives phenotype and that can be altered
by environmental exposures including radiation. The majority of human radiation exposures …

The effects of ionizing radiation on DNA methylation are of importance due to the role that
DNA methylation plays in maintaining genome stability, and the presence of aberrant DNA …

Background Proton irradiation poses a potential hazard to astronauts during and following a
mission, with post-mitotic cells at most risk because they cannot dilute resultant epigenetic …

Cardiovascular disease constitutes an important threat to humans after space missions
beyond the Earth's magnetosphere. Epigenetic alterations have an important role in the …

Purpose: Ionizing radiation (IR) is a ubiquitous environmental stressor with genotoxic and
epigenotoxic capabilities. Terrestrial IR, predominantly a low-linear energy transfer (LET) …

The biological and genetic effects of chronic low-dose radiation (LDR) exposure and its
relationship to carcinogenesis have received a lot of attention in the recent years. For …

Epigenetics, including DNA methylation and microRNA (miRNA) expression, could be the
missing link in understanding radiation-induced genomic instability (RIGI). This study tests …

Radiation-Induced CardioVascular Disease (RICVD) is an important concern in thoracic
radiotherapy with complex underlying pathophysiology. Recently, we proposed DNA …

Radiation-induced lymphomagenesis and leukemogenesis are complex processes
involving both genetic and epigenetic changes. Although genetic alterations during radiation …