Human lymphocytes have recently been described as an important physiological source of
melatonin (N‐acetyl‐5‐methoxytryptamine), which could be involved in the regulation of the …

It has been historically assumed that the pineal gland is the major source of melatonin (N‐
acetyl‐5‐methoxytryptamine) in vertebrates. Melatonin plays a central role in fine‐tuning …

Since melatonin was first isolated in 1958 up to the last few years, this substance was
considered a hormone exclusive to the pineal gland. Although melatonin has lately been …

Melatonin could act on immune system by regulating cytokine production of
immunocompetent cells. The hormone enhances IL-2, IFN-γ and IL-6 production by cultured …

It is well known that melatonin plays a fundamental role in human neuro‐
immunomodulation. Thus, melatonin regulates the production of a large number of …

This report shows that melatonin enhances IL‐2 production by Jurkat cells via a nuclear
receptor‐mediated mechanism. Jurkat cells express nuclear (RZRα, RORα1, and RORα2) …

This report shows that melatonin enhances IL-6 production by U937 cells via a nuclear
receptor-mediated mechanism. Resting U937 cells only express membrane (mt1) melatonin …

Earlier studies have shown that the pineal hormone melatonin activates human monocytes.
It is reported here that melatonin induces the secretion of IL-1, IL-6, and TNF in fresh and 1 …

Melatonin has been proposed as regulating the immune system by affecting cytokine
production in immunocompetent cells, enhancing the production of several T helper (Th) 1 …

Cultured human peripheral blood mononuclear leucocytes (PBML) were able to synthesize
indoleamines, including melatonin, and were also able to convert melatonin taken up from …