Several teleosts, such as the zebrafish and the medakafish or medaka (Oryzias latipes), are
used as vertebrate model systems in various fields of biology. The medaka is suitable for …

Small laboratory fish such as medaka and zebrafish have been used for studies of
development and genetics in vertebrates for many years. Their advantages for use in these …

A large-scale mutagenesis screen was performed in Medaka to identify genes acting in
diverse developmental processes. Mutations were identified in homozygous F3 progeny …

In a pilot screen, we assayed the efficiency of ethylnitrosourea (ENU) as a chemical
mutagen to induce mutations that lead to early embryonic and larval lethal phenotypes in the …

Comparison of two related species is one of the most successful approaches to decipher
general genetic principles in eukaryotes. This is best illustrated in yeast, where the model …

Genome sequencing has yielded a plethora of new genes the function of which can be
unravelled through comparative genomic approaches. Increasingly, developmental …

The identification of genes via their mutant phenotypes is the most direct way of dissecting
the molecular basis of developmental processes. While this approach has been extremely …

In a large-scale screen, we isolated mutants displaying a specific visible phenotype in
embryos or early larvae of the zebrafish, Danio rerio. Males were mutagenized with …

Systematic genome-wide mutagenesis screens for embryonic phenotypes have been
instrumental in the understanding of invertebrate and plant development. Here, we report …

Recent advances in medaka genetics have proven that the medakafish is an excellent
model system for developmental and evolutionary biology studies and that it can …