Role of CpG deserts in the epigenetic transgenerational inheritance of differential DNA methylation regions

MK Skinner, C Guerrero-Bosagna - Bmc Genomics, 2014 - Springer
Background Previously a variety of environmental toxicants were found to promote the
epigenetic transgenerational inheritance of disease through differential DNA methylation …

Identification of genomic features in environmentally induced epigenetic transgenerational inherited sperm epimutations

C Guerrero-Bosagna, S Weeks, MK Skinner - PloS one, 2014 - journals.plos.org
A variety of environmental toxicants have been shown to induce the epigenetic
transgenerational inheritance of disease and phenotypic variation. The process involves …

Genomic Clustering of differential DNA methylated regions (epimutations) associated with the epigenetic transgenerational inheritance of disease and phenotypic …

MM Haque, EE Nilsson, LB Holder, MK Skinner - BMC genomics, 2016 - Springer
Background A variety of environmental factors have been shown to promote the epigenetic
transgenerational inheritance of disease and phenotypic variation in numerous species …

Generational comparisons (F1 versus F3) of vinclozolin induced epigenetic transgenerational inheritance of sperm differential DNA methylation regions (epimutations) …

D Beck, I Sadler-Riggleman… - Environmental …, 2017 - academic.oup.com
Environmentally induced epigenetic transgenerational inheritance of disease and
phenotypic variation has been shown to involve DNA methylation alterations in the germline …

Environmentally induced epigenetic transgenerational inheritance of sperm epimutations promote genetic mutations

MK Skinner, C Guerrero-Bosagna, MM Haque - Epigenetics, 2015 - Taylor & Francis
A variety of environmental factors have been shown to induce the epigenetic
transgenerational inheritance of disease and phenotypic variation. This involves the …

Alterations in sperm DNA methylation, non-coding RNA and histone retention associate with DDT-induced epigenetic transgenerational inheritance of disease

MK Skinner, M Ben Maamar, I Sadler-Riggleman… - Epigenetics & …, 2018 - Springer
Background Environmental toxicants such as DDT have been shown to induce the
epigenetic transgenerational inheritance of disease (eg, obesity) through the germline. The …

[HTML][HTML] Developmental origins of transgenerational sperm DNA methylation epimutations following ancestral DDT exposure

MB Maamar, E Nilsson, I Sadler-Riggleman… - Developmental …, 2019 - Elsevier
Epigenetic alterations in the germline can be triggered by a number of different
environmental factors from diet to toxicants. These environmentally induced germline …

Epigenetic inheritance is unfaithful at intermediately methylated CpG sites

AD Hay, NJ Kessler, D Gebert, N Takahashi… - Nature …, 2023 - nature.com
DNA methylation at the CpG dinucleotide is considered a stable epigenetic mark due to its
presumed long-term inheritance through clonal expansion. Here, we perform high …

Epigenome-wide association study for pesticide (Permethrin and DEET) induced DNA methylation epimutation biomarkers for specific transgenerational disease

JLM Thorson, D Beck, M Ben Maamar, EE Nilsson… - Environmental …, 2020 - Springer
Abstract Background Permethrin and N, N-diethyl-meta-toluamide (DEET) are the pesticides
and insect repellent most commonly used by humans. These pesticides have been shown to …

Pesticide and insect repellent mixture (permethrin and DEET) induces epigenetic transgenerational inheritance of disease and sperm epimutations

M Manikkam, R Tracey, C Guerrero-Bosagna… - Reproductive …, 2012 - Elsevier
Environmental compounds are known to promote epigenetic transgenerational inheritance
of disease. The current study was designed to determine if a “pesticide mixture”(pesticide …