Integrin-linked kinase signaling promotes cyst growth and fibrosis in polycystic kidney disease
A Raman, GA Reif, Y Dai, A Khanna, X Li… - Journal of the …, 2017 - journals.lww.com
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by innumerous
fluid-filled cysts and progressive deterioration of renal function. Previously, we showed that …
fluid-filled cysts and progressive deterioration of renal function. Previously, we showed that …
[HTML][HTML] Periostin promotes renal cyst growth and interstitial fibrosis in polycystic kidney disease
DP Wallace, C White, L Savinkova, E Nivens, GA Reif… - Kidney international, 2014 - Elsevier
In renal cystic diseases, sustained enlargement of fluid-filled cysts is associated with severe
interstitial fibrosis and progressive loss of functioning nephrons. Periostin, a matricellular …
interstitial fibrosis and progressive loss of functioning nephrons. Periostin, a matricellular …
Periostin overexpression in collecting ducts accelerates renal cyst growth and fibrosis in polycystic kidney disease
In polycystic kidney disease (PKD), persistent activation of cell proliferation and matrix
production contributes to cyst growth and fibrosis, leading to progressive deterioration of …
production contributes to cyst growth and fibrosis, leading to progressive deterioration of …
Periostin is involved in cell proliferation and interstitial fibrosis in polycystic kidney disease
E Bible - Nature Reviews Nephrology, 2014 - nature.com
Periostin is overexpressed in autosomal dominant polycystic kidney disease (ADPKD) and
in mice with polycystic kidney disease (PKD). Darren Wallace and colleagues at the …
in mice with polycystic kidney disease (PKD). Darren Wallace and colleagues at the …
Extracellular matrix, integrins, and focal adhesion signaling in polycystic kidney disease
Y Zhang, G Reif, DP Wallace - Cellular signalling, 2020 - Elsevier
In autosomal dominant polycystic kidney disease (ADPKD), the inexorable growth of
numerous fluid-filled cysts leads to massively enlarged kidneys, renal interstitial damage …
numerous fluid-filled cysts leads to massively enlarged kidneys, renal interstitial damage …
Periostin induces proliferation of human autosomal dominant polycystic kidney cells through αV-integrin receptor
DP Wallace, MT Quante, GA Reif… - American Journal …, 2008 - journals.physiology.org
Progressive renal enlargement due to the growth of innumerable fluid-filled cysts is a central
pathophysiological feature of autosomal dominant polycystic kidney disease (ADPKD) …
pathophysiological feature of autosomal dominant polycystic kidney disease (ADPKD) …
Periostin in the Kidney
DP Wallace - Periostin, 2019 - Springer
Periostin is a matricellular protein that is expressed in several tissues during embryonic
development; however, its expression in adults is mostly restricted to collagen-rich …
development; however, its expression in adults is mostly restricted to collagen-rich …
Interleukin-1 receptor activation aggravates autosomal dominant polycystic kidney disease by modulating regulated necrosis
Autosomal dominant polycystic kidney disease (ADPKD) is associated with increased
chemokines, cytokines, and growth factors in the diseased kidney. We found that both …
chemokines, cytokines, and growth factors in the diseased kidney. We found that both …
Inactivation of integrin-β1 prevents the development of polycystic kidney disease after the loss of polycystin-1
K Lee, S Boctor, LMC Barisoni… - Journal of the American …, 2015 - journals.lww.com
Abstract Dysregulation of polycystin-1 (PC1) leads to autosomal dominant polycystic kidney
disease (ADPKD), a disorder characterized by the formation of multiple bilateral renal cysts …
disease (ADPKD), a disorder characterized by the formation of multiple bilateral renal cysts …
Integrin-linked kinase deficiency in collecting duct principal cell promotes necroptosis of principal cell and contributes to kidney inflammation and fibrosis
M Huang, S Zhu, H Huang, J He, K Tsuji… - Journal of the …, 2019 - journals.lww.com
Background Necroptosis is a newly discovered cell death pathway that plays a critical role in
AKI. The involvement of integrin-linked kinase (ILK) in necroptosis has not been studied …
AKI. The involvement of integrin-linked kinase (ILK) in necroptosis has not been studied …
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