Autosomal dominant polycystic kidney disease (ADPKD) is characterized by innumerous
fluid-filled cysts and progressive deterioration of renal function. Previously, we showed that …

In renal cystic diseases, sustained enlargement of fluid-filled cysts is associated with severe
interstitial fibrosis and progressive loss of functioning nephrons. Periostin, a matricellular …

In polycystic kidney disease (PKD), persistent activation of cell proliferation and matrix
production contributes to cyst growth and fibrosis, leading to progressive deterioration of …

In autosomal dominant polycystic kidney disease (ADPKD), the inexorable growth of
numerous fluid-filled cysts leads to massively enlarged kidneys, renal interstitial damage …

Periostin is overexpressed in autosomal dominant polycystic kidney disease (ADPKD) and
in mice with polycystic kidney disease (PKD). Darren Wallace and colleagues at the …

Progressive renal enlargement due to the growth of innumerable fluid-filled cysts is a central
pathophysiological feature of autosomal dominant polycystic kidney disease (ADPKD) …

Periostin is a matricellular protein that is expressed in several tissues during embryonic
development; however, its expression in adults is mostly restricted to collagen-rich …

Autosomal dominant polycystic kidney disease (ADPKD) is associated with increased
chemokines, cytokines, and growth factors in the diseased kidney. We found that both …

Abstract Dysregulation of polycystin-1 (PC1) leads to autosomal dominant polycystic kidney
disease (ADPKD), a disorder characterized by the formation of multiple bilateral renal cysts …

Background Necroptosis is a newly discovered cell death pathway that plays a critical role in
AKI. The involvement of integrin-linked kinase (ILK) in necroptosis has not been studied …