Autosomal dominant polycystic kidney disease (ADPKD) affects more than 500,000
individuals in the United States alone. In most cases, ADPKD is caused by a loss-of-function …

Polycystic kidney disease (PKD) is an inherited disorder that is characterized by the
accumulation of cysts in the renal parenchyma and progressive decline in renal function …

Polycystic kidney disease is an inherited degenerative disease in which the uriniferous
tubules are replaced by expanding fluid-filled cysts that ultimately destroy organ function …

Autosomal dominant polycystic kidney disease (ADPKD) is a commonly inherited disorder
mostly caused by mutations in PKD1, encoding polycystin-1 (PC1). The disease is …

Autosomal-dominant polycystic kidney disease (ADPKD) is caused by mutations in either
PKD1 or PKD2 and is characterized by the development of multiple bilateral renal cysts that …

Polycystic kidney disease is the most common heritable disease in humans. In addition to
epithelial cysts in the kidney, liver and pancreas, patients with autosomal dominant …

Autosomal dominant polycystic kidney disease (ADPKD) is the most common human
monogenic genetic disorder and is characterized by progressive bilateral renal cysts and the …

This study investigated whether integrin-linked kinase (ILK) is involved in the pathogenesis
of chronic glomerulonephritis (GN) by analyzing the expression and activity of glomerular …

Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the presence of
numerous fluid-filled cysts, extensive fibrosis, and the progressive decline in kidney function …

Background Mutations in PKD1 or PKD2 cause typical autosomal dominant polycystic
kidney disease (ADPKD), the most common monogenic kidney disease. Dominantly …