Principles and challenges of genome-wide DNA methylation analysis

PW Laird - Nature Reviews Genetics, 2010 - nature.com
Methylation of cytosine bases in DNA provides a layer of epigenetic control in many
eukaryotes that has important implications for normal biology and disease. Therefore …

DNA methylation methods: Global DNA methylation and methylomic analyses

S Li, TO Tollefsbol - Methods, 2021 - Elsevier
DNA methylation provides a pivotal layer of epigenetic regulation in eukaryotes that has
significant involvement for numerous biological processes in health and disease. The …

DNA methylation: a timeline of methods and applications

A Harrison, A Parle-McDermott - Frontiers in genetics, 2011 - frontiersin.org
DNA methylation is a biochemical process where a DNA base, usually cytosine, is
enzymatically methylated at the 5-carbon position. An epigenetic modification associated …

Analysing and interpreting DNA methylation data

C Bock - Nature Reviews Genetics, 2012 - nature.com
DNA methylation is an epigenetic mark that has suspected regulatory roles in a broad range
of biological processes and diseases. The technology is now available for studying DNA …

Profiling genome-wide DNA methylation

WS Yong, FM Hsu, PY Chen - Epigenetics & chromatin, 2016 - Springer
DNA methylation is an epigenetic modification that plays an important role in regulating
gene expression and therefore a broad range of biological processes and diseases. DNA …

Deciphering the epigenetic code: an overview of DNA methylation analysis methods

M Umer, Z Herceg - Antioxidants & redox signaling, 2013 - liebertpub.com
Significance: Methylation of cytosine in DNA is linked with gene regulation, and this has
profound implications in development, normal biology, and disease conditions in many …

Methods in DNA methylation profiling

T Zuo, B Tycko, TM Liu, HJL Lin, THM Huang - Epigenomics, 2009 - Taylor & Francis
Metastable and somatically heritable patterns of DNA methylation provide an important level
of genomic regulation. In this article, we review methods for analyzing these genome-wide …

Profiling DNA methylomes from microarray to genome-scale sequencing

YW Huang, THM Huang… - Technology in cancer …, 2010 - journals.sagepub.com
DNA cytosine methylation is a central epigenetic modification which plays critical roles in
cellular processes including genome regulation, development and disease. Here, we review …

Genome-wide analysis of DNA methylation patterns

D Zilberman, S Henikoff - 2007 - journals.biologists.com
Cytosine methylation is the most common covalent modification of DNA in eukaryotes. DNA
methylation has an important role in many aspects of biology, including development and …

Genome‐wide DNA methylation profiling

M Bibikova, JB Fan - Wiley Interdisciplinary Reviews: Systems …, 2010 - Wiley Online Library
DNA methylation plays a critical role in the regulation of gene expression. The ability to
access the methylation status for a large number of genes or the entire genome should …