To date, nearly 100 autoimmune diseases have been an area of focus, and these diseases
bring health challenges to approximately 5% of the population worldwide. As a type of …

Immune cells are one of the most complex and diverse systems in the human organism.
Such diversity implies an intricate network of different cell types and interactions that are …

B lymphocytes play key roles in adaptive and innate immunity. In autoimmune diseases,
their participation in disease instigation and/or progression has been demonstrated in both …

Epigenetic mechanisms, such as DNA methylation, histone modifications, and non-coding
RNAs are known regulators of gene expression and genomic stability in cell growth …

DNA methylation is a dynamic epigenetic modification with a prominent role in determining
mammalian cell development, lineage identity, and transcriptional regulation. Primarily …

Epigenetics functions as a bridge between host genetic & environmental factors, aiding in
human health and diseases. Many immune-related diseases, including infectious and …

DNA methylation is now widely recognized as being critical to maintain the function of
immune cells. Recent studies suggest that aberrant DNA methylation levels not only can …

During hematopoiesis, a unique hematopoietic stem cell (HSC) from the bone marrow gives
rise to a subset of mature blood cells that directs all the immune responses. Recent studies …

Epigenetic reprogramming underlies specification of immune cell lineages, but patterns that
uniquely define immune cell types and the mechanisms by which they are established …

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease facilitated by
aberrant immune responses directed against cells and tissues, resulting in inflammation and …