Aging is the most important risk factor for the development of most adult malignancies. The
molecular events responsible for this striking association remain under investigation, but …

Mammalian cells have a finite proliferative lifespan, at the end of which they are unable to
enter S phase in response to mitogenic stimuli. They undergo morphological changes and …

Alterations in methylation are widespread in cancers. DNA methylation of promoter-
associated CpG islands is an alternate mechanism to mutation in silencing gene function …

DNA methylation of promoter-associated CpG islands may function as an alternate
mechanism of silencing tumor suppressor genes in multiple neoplasias including colorectal …

Cancer development and progression is dictated by a series of alterations in genes such as
oncogenes, tumor suppressor genes, DNA repair genes, and others. DNA methylation is an …

CpG islands are short stretches of CpG rich regions that are frequently associated with the
promoter region of genes. Aberrant methylation of CpG islands is one mechanism of …

Aberrant methylation of promoter CpG islands in cancer is associated with silencing of tumor-
suppressor genes, and age-dependent hypermethylation in normal appearing mucosa may …

Epigenetic gene silencing through DNA methylation is now clearly thought to be one of the
important steps in the mechanism underlying tumourigenesis. The methylation of several …

Statistics rate colorectal adenocarcinoma as the most common cause of cancer death on
exclusion of smoking‐related neoplasia. However, the reported accumulation of genetic …

Cancer and aging are two coupled developmental processes as reflected by the higher
incidence of cancer in the elderly human population group. Genetic mutations accumulate in …