The malignant transformation of normal cells is driven by both genetic and epigenetic
changes. With the advent of next-generation sequencing and large-scale multinational …

DNA methylation is a highly regulated process that has a critical role in human development
and homeostatic control of the cell. The number of genes affected by anomalous DNA …

Recent conceptual advances in the field of DNA methylation and the advent and rapid
development of new technologies in epigenomics have started to unravel the mechanisms …

DNA methylation plays an important role in the silence of tissue-specific genes to prevent
them from being expressed in the wrong tissue. Aberrant DNA methylation (genome-wide …

DNA methylation is one among the major grounds of cancer progression which is
characterized by the addition of a methyl group to the promoter region of the gene thereby …

Cancer cells typically exhibit aberrant DNA methylation patterns that can drive malignant
transformation. Whether cancer cells are dependent on these abnormal epigenetic …

The epigenome, which is comprised of chromatin and its associated proteins and the
patterns of covalent modification of DNA by methylation, sets up and maintains gene …

DNA methylation is one of the essential epigenetic mechanisms that are closely correlated
with the mechanisms underlying cell growth, differentiation and transformation in …

Cells encounter a multitude of external and internal stress-causing agents that can ultimately
lead to DNA damage, mutations and disease. A cascade of signaling events counters these …

The spatial arrangement and three-dimensional structure of DNA in the nucleus is controlled
through the interdigitation of DNA binding proteins such as histones and their modifiers, the …