The role of DNA methylation in cancer
R Lakshminarasimhan, G Liang - DNA Methyltransferases-Role and …, 2016 - Springer
The malignant transformation of normal cells is driven by both genetic and epigenetic
changes. With the advent of next-generation sequencing and large-scale multinational …
changes. With the advent of next-generation sequencing and large-scale multinational …
Use of DNA methylation profiling in translational oncology
V Ortiz-Barahona, RS Joshi, M Esteller - Seminars in cancer biology, 2022 - Elsevier
DNA methylation is a highly regulated process that has a critical role in human development
and homeostatic control of the cell. The number of genes affected by anomalous DNA …
and homeostatic control of the cell. The number of genes affected by anomalous DNA …
DNA methylation and cancer: ghosts and angels above the genes
Recent conceptual advances in the field of DNA methylation and the advent and rapid
development of new technologies in epigenomics have started to unravel the mechanisms …
development of new technologies in epigenomics have started to unravel the mechanisms …
[HTML][HTML] DNA methylation: from cancer biology to clinical perspectives
C Chen, Z Wang, Y Ding, L Wang, S Wang… - Frontiers in Bioscience …, 2022 - imrpress.com
DNA methylation plays an important role in the silence of tissue-specific genes to prevent
them from being expressed in the wrong tissue. Aberrant DNA methylation (genome-wide …
them from being expressed in the wrong tissue. Aberrant DNA methylation (genome-wide …
DNA methylation and cancer: transcriptional regulation, prognostic, and therapeutic perspective
DNA methylation is one among the major grounds of cancer progression which is
characterized by the addition of a methyl group to the promoter region of the gene thereby …
characterized by the addition of a methyl group to the promoter region of the gene thereby …
DNA methylation screening identifies driver epigenetic events of cancer cell survival
DD De Carvalho, S Sharma, JS You, SF Su… - Cancer cell, 2012 - cell.com
Cancer cells typically exhibit aberrant DNA methylation patterns that can drive malignant
transformation. Whether cancer cells are dependent on these abnormal epigenetic …
transformation. Whether cancer cells are dependent on these abnormal epigenetic …
DNA demethylation and cancer: therapeutic implications
M Szyf, P Pakneshan, SA Rabbani - Cancer letters, 2004 - Elsevier
The epigenome, which is comprised of chromatin and its associated proteins and the
patterns of covalent modification of DNA by methylation, sets up and maintains gene …
patterns of covalent modification of DNA by methylation, sets up and maintains gene …
DNA methylation as an early diagnostic marker of cancer
DNA methylation is one of the essential epigenetic mechanisms that are closely correlated
with the mechanisms underlying cell growth, differentiation and transformation in …
with the mechanisms underlying cell growth, differentiation and transformation in …
Making it or breaking it: DNA methylation and genome integrity
Cells encounter a multitude of external and internal stress-causing agents that can ultimately
lead to DNA damage, mutations and disease. A cascade of signaling events counters these …
lead to DNA damage, mutations and disease. A cascade of signaling events counters these …
DNA methylation in health, disease, and cancer
DS Shames, JD Minna… - Current molecular …, 2007 - ingentaconnect.com
The spatial arrangement and three-dimensional structure of DNA in the nucleus is controlled
through the interdigitation of DNA binding proteins such as histones and their modifiers, the …
through the interdigitation of DNA binding proteins such as histones and their modifiers, the …