[PDF][PDF] Phenotypic landscape of schizophrenia-associated genes defines candidates and their shared functions
Genomic studies have identified hundreds of candidate genes near loci associated with risk
for schizophrenia. To define candidates and their functions, we mutated zebrafish orthologs …
for schizophrenia. To define candidates and their functions, we mutated zebrafish orthologs …
The association between schizophrenia and the immune system: Review of the evidence from unbiased 'omic-studies'
HC van Mierlo, A Schot, MPM Boks, LD de Witte - Schizophrenia research, 2020 - Elsevier
A role for immune processes in the pathogenesis of schizophrenia has been suggested by
genetic and epidemiological studies, as well as cross-sectional studies on blood and brain …
genetic and epidemiological studies, as well as cross-sectional studies on blood and brain …
Consensus molecular environment of schizophrenia risk genes in coexpression networks shifting across age and brain regions
Schizophrenia is a neurodevelopmental brain disorder whose genetic risk is associated with
shifting clinical phenomena across the life span. We investigated the convergence of …
shifting clinical phenomena across the life span. We investigated the convergence of …
[HTML][HTML] Schizophrenia: susceptibility genes and oligodendroglial and myelin related abnormalities
P Roussos, V Haroutunian - Frontiers in cellular neuroscience, 2014 - frontiersin.org
Given that the genetic risk for schizophrenia is highly polygenic and the effect sizes, even for
rare or de novo events, are modest at best, it has been suggested that multiple biological …
rare or de novo events, are modest at best, it has been suggested that multiple biological …
Epigenetics and gene expression profile in first-episode psychosis: The role of childhood trauma
Childhood Trauma (CT) mediation of the epigenome and its impact on gene expression
profile could provide a mechanism for the gene-environment interaction underling …
profile could provide a mechanism for the gene-environment interaction underling …
Genetics of schizophrenia: ready to translate?
Abstract Purpose of Review This is an era where we have significantly advanced the
understanding of the genetic architecture of schizophrenia. In this review, we consider how …
understanding of the genetic architecture of schizophrenia. In this review, we consider how …
Boosting the power of schizophrenia genetics by leveraging new statistical tools
OA Andreassen, WK Thompson… - Schizophrenia …, 2014 - academic.oup.com
Genome-wide association studies (GWAS) have identified a large number of gene variants
associated with schizophrenia, but these variants explain only a small portion of the …
associated with schizophrenia, but these variants explain only a small portion of the …
Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia pathogenesis
Genome-wide association studies have identified 108 schizophrenia risk loci, but biological
mechanisms for individual loci are largely unknown. Using developmental, genetic and …
mechanisms for individual loci are largely unknown. Using developmental, genetic and …
Genome-wide association study identifies five new schizophrenia loci
Nature genetics, 2011 - nature.com
We examined the role of common genetic variation in schizophrenia in a genome-wide
association study of substantial size: a stage 1 discovery sample of 21,856 individuals of …
association study of substantial size: a stage 1 discovery sample of 21,856 individuals of …
Genetic risk for schizophrenia: convergence on synaptic pathways involved in plasticity
J Hall, S Trent, KL Thomas, MC O'Donovan… - Biological psychiatry, 2015 - Elsevier
Recent large-scale genomic studies have revealed two broad classes of risk alleles for
schizophrenia: a polygenic component of risk mediated through multiple common risk …
schizophrenia: a polygenic component of risk mediated through multiple common risk …