A variety of animal models have been developed to better understand the pathophysiology
of AAA. The 3 most commonly used mouse AAA models are adventitial exposure to calcium …

Objective—The role of TGF-β (transforming growth factor-β) signaling in abdominal aortic
aneurysm (AAA) formation is controversial. Others reported that systemic blockade of TGF-β …

Many mouse models of abdominal aortic aneurysms have been developed that use a
diverse array of methods for producing the disease, including genetic manipulation and …

Abdominal aortic aneurysms (AAAs) are an increasingly common and potentially lethal
condition. Surgical repair of AAA is now yet performed quite safely, yet ruptured AAAs still …

Abdominal aortic aneurysm (AAA) is a prevalent and potentially life threatening disease.
Many animal models have been developed to simulate the natural history of the disease or …

Abdominal aortic aneurysms (AAA) have a high prevalence in aged populations and are
responsible for a large number of deaths. Despite the widespread nature of the disease …

Objective—Abdominal aortic aneurysms (AAAs) are common, but their exact pathogenesis
remains unknown and no specific medical therapies are available. We sought to evaluate …

Background—Thoracic aortic aneurysms (TAAs) are common, but experimental TAA models
are limited and the role of interleukin-1β (IL-1β) is undetermined. Methods and Results—IL …

Abdominal aortic aneurysms (AAAs) represent a complex degenerative disorder involving
chronic aortic wall inflammation and destructive remodeling of structural connective tissue …

Objective—Current experimental models of abdominal aortic aneurysm (AAA) do not
accurately reproduce the major features of human AAA. We hypothesized that blockade of …