[PDF][PDF] Divergent effects of Dnmt3a and Tet2 mutations on hematopoietic progenitor cell fitness
The DNA methylation regulators DNMT3A and TET2 are recurrently mutated in
hematological disorders. Despite possessing antagonistic biochemical activities, loss-of …
hematological disorders. Despite possessing antagonistic biochemical activities, loss-of …
[HTML][HTML] Epigenetic modification of cytosines in hematopoietic differentiation and malignant transformation
J An, M Ko - International Journal of Molecular Sciences, 2023 - mdpi.com
The mammalian DNA methylation landscape is established and maintained by the
combined activities of the two key epigenetic modifiers, DNA methyltransferases (DNMT) …
combined activities of the two key epigenetic modifiers, DNA methyltransferases (DNMT) …
DNA methylation disruption reshapes the hematopoietic differentiation landscape
Mutations in genes involved in DNA methylation (DNAme; for example, TET2 and DNMT3A)
are frequently observed in hematological malignancies,–and clonal hematopoiesis …
are frequently observed in hematological malignancies,–and clonal hematopoiesis …
DNMT3A haploinsufficiency causes dichotomous DNA methylation defects at enhancers in mature human immune cells
JY Lim, SH Duttke, TS Baker, J Lee… - Journal of Experimental …, 2021 - rupress.org
DNMT3A encodes an enzyme that carries out de novo DNA methylation, which is essential
for the acquisition of cellular identity and specialized functions during cellular differentiation …
for the acquisition of cellular identity and specialized functions during cellular differentiation …
[PDF][PDF] DNA methyltransferase 1 is essential for and uniquely regulates hematopoietic stem and progenitor cells
DNA methylation is essential for development and in diverse biological processes. The DNA
methyltransferase Dnmt1 maintains parental cell methylation patterns on daughter DNA …
methyltransferase Dnmt1 maintains parental cell methylation patterns on daughter DNA …
[HTML][HTML] Impact of constitutional TET2 haploinsufficiency on molecular and clinical phenotype in humans
E Kaasinen, O Kuismin, K Rajamäki… - Nature …, 2019 - nature.com
Clonal hematopoiesis driven by somatic heterozygous TET2 loss is linked to malignant
degeneration via consequent aberrant DNA methylation, and possibly to cardiovascular …
degeneration via consequent aberrant DNA methylation, and possibly to cardiovascular …
Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation
A Mayle, L Yang, B Rodriguez, T Zhou… - Blood, The Journal …, 2015 - ashpublications.org
Abstract DNA methyltransferase 3A (DNMT3A) is mutated in hematologic malignancies
affecting myeloid, mixed, and lymphoid lineages, and these mutations are associated with …
affecting myeloid, mixed, and lymphoid lineages, and these mutations are associated with …
[HTML][HTML] Dnmt3a and Dnmt3b have overlapping and distinct functions in hematopoietic stem cells
Epigenetic regulation of hematopoietic stem cells (HSCs) ensures lifelong production of
blood and bone marrow. Recently, we reported that loss of de novo DNA methyltransferase …
blood and bone marrow. Recently, we reported that loss of de novo DNA methyltransferase …
[PDF][PDF] Tissue-biased expansion of DNMT3A-mutant clones in a mosaic individual is associated with conserved epigenetic erosion
Summary DNA methyltransferase 3A (DNMT3A) is the most commonly mutated gene in
clonal hematopoiesis (CH). Somatic DNMT3A mutations arise in hematopoietic stem cells …
clonal hematopoiesis (CH). Somatic DNMT3A mutations arise in hematopoietic stem cells …
[PDF][PDF] Loss of Dnmt3a immortalizes hematopoietic stem cells in vivo
Somatic mutations in DNMT3A are recurrent events across a range of blood cancers.
Dnmt3a loss of function in hematopoietic stem cells (HSCs) skews divisions toward self …
Dnmt3a loss of function in hematopoietic stem cells (HSCs) skews divisions toward self …