To investigate the role of DNA methylation during human development, we developed
Methyl-seq, a method that assays DNA methylation at more than 90,000 regions throughout …

DNA methylation is a critical epigenetic regulator in mammalian development. Here, we
present a whole-genome comparative view of DNA methylation using bisulfite sequencing of …

Background We performed a comparative analysis of the genome-wide DNA methylation
profiles from three human embryonic stem cell (HESC) lines. It had previously been shown …

The generation of genome-wide data derived from methylated DNA immunoprecipitation
followed by sequencing (MeDIP-seq) has become a major tool for epigenetic studies in …

DNA methylation is a tightly regulated epigenetic mark associated with transcriptional
repression. Next-generation sequencing of purified methylated DNA obtained from early …

Cytosine DNA methylation is essential for mammalian development but understanding of its
spatiotemporal distribution in the developing embryo remains limited,. Here, as part of the …

The faithful transmission of DNA methylation patterns through cell divisions is essential for
the daughter cells to retain a proper cell identity. To achieve a comprehensive assessment …

Remodelling the methylome is a hallmark of mammalian development and cell
differentiation. However, current knowledge of DNA methylation dynamics in human tissue …

The question of whether DNA methylation contributes to the stabilization of gene expression
patterns in differentiated mammalian tissues remains controversial. Using genome-wide …

Background DNA methylation is of pivotal importance during development. Previous
genome-wide studies identified numerous differentially methylated regions upon …