[HTML][HTML] Reversible regulation of promoter and enhancer histone landscape by DNA methylation in mouse embryonic stem cells
DNA methylation is one of a number of modes of epigenetic gene regulation. Here, we
profile the DNA methylome, transcriptome, and global occupancy of histone modifications …
profile the DNA methylome, transcriptome, and global occupancy of histone modifications …
Methylomic trajectories across human fetal brain development
Epigenetic processes play a key role in orchestrating transcriptional regulation during
development. The importance of DNA methylation in fetal brain development is highlighted …
development. The importance of DNA methylation in fetal brain development is highlighted …
Genome-scale DNA methylation maps of pluripotent and differentiated cells
DNA methylation is essential for normal development,, and has been implicated in many
pathologies including cancer,. Our knowledge about the genome-wide distribution of DNA …
pathologies including cancer,. Our knowledge about the genome-wide distribution of DNA …
Quantitative comparison of genome-wide DNA methylation mapping technologies
DNA methylation plays a key role in regulating eukaryotic gene expression. Although
mitotically heritable and stable over time, patterns of DNA methylation frequently change in …
mitotically heritable and stable over time, patterns of DNA methylation frequently change in …
Human DNA methylomes at base resolution show widespread epigenomic differences
DNA cytosine methylation is a central epigenetic modification that has essential roles in
cellular processes including genome regulation, development and disease. Here we …
cellular processes including genome regulation, development and disease. Here we …
[HTML][HTML] Whole-genome mapping of histone H3 Lys4 and 27 trimethylations reveals distinct genomic compartments in human embryonic stem cells
XD Zhao, X Han, JL Chew, J Liu, KP Chiu, A Choo… - Cell stem cell, 2007 - cell.com
Epigenetic modifications are crucial for proper lineage specification and embryo
development. To explore the chromatin modification landscapes in human ES cells, we …
development. To explore the chromatin modification landscapes in human ES cells, we …
[HTML][HTML] Genome-wide analysis in the mouse embryo reveals the importance of DNA methylation for transcription integrity
T Dahlet, A Argüeso Lleida, H Al Adhami… - Nature …, 2020 - nature.com
Mouse embryos acquire global DNA methylation of their genome during implantation.
However the exact roles of DNA methyltransferases (DNMTs) in embryos have not been …
However the exact roles of DNA methyltransferases (DNMTs) in embryos have not been …
[HTML][HTML] Tissue-specific DNA methylation is conserved across human, mouse, and rat, and driven by primary sequence conservation
Background Uncovering mechanisms of epigenome evolution is an essential step towards
understanding the evolution of different cellular phenotypes. While studies have confirmed …
understanding the evolution of different cellular phenotypes. While studies have confirmed …
[HTML][HTML] Postnatal epigenetic regulation of intestinal stem cells requires DNA methylation and is guided by the microbiome
Background DNA methylation is an epigenetic mechanism central to development and
maintenance of complex mammalian tissues, but our understanding of its role in intestinal …
maintenance of complex mammalian tissues, but our understanding of its role in intestinal …
Genome‐wide and locus‐specific DNA hypomethylation in G9a deficient mouse embryonic stem cells
In the mammalian genome, numerous CpG‐rich loci define tissue‐dependent and
differentially methylated regions (T‐DMRs). Euchromatin from different cell types differs in …
differentially methylated regions (T‐DMRs). Euchromatin from different cell types differs in …