Highlights•DNA methylation is an important epigenetic mechanism regulating gene
expression.•DNA methyltransferases add repressing or activating methyl “marks” to …

The study of DNA methylation has been a rapidly expanding field since its dawn in the
1960s. DNA methylation is an epigenetic modification that plays a crucial role in guiding the …

Epigenome regulation is a critical mechanism that governs cell identity, lineage specification
and developmental cell fates. With the advent of low-input and single-cell technologies as …

DNA methylation is a well-studied epigenetic modification essential for efficient cellular
differentiation. Aberrant DNA methylation patterns are a characteristic feature of cancer …

Highlights•DNA and RNA methylation is implicated in normal and aberrant
hematopoiesis.•These epigenetic marks are exploited in cancer to evade immune …

Hematopoietic stem cells give rise to all blood cells in a differentiation process that involves
widespread epigenome remodeling. Here we present genome-wide reference maps of the …

The rapid advances in high‐throughput sequencing technologies have made it more evident
that epigenetic modifications orchestrate a plethora of complex biological processes. During …

DNA methylation provides a major epigenetic code (besides histone modification) of the
lineage-and developmentspecific genes (such as regulators of differentiation in the …

DNA methylation plays an important role in the self-renewal of hematopoietic stem cells and
in the commitment to the lymphoid or myeloid lineages. Using purified CD34+ hematopoietic …

DNA methyltransferases (DNMTs) are the key enzymes for genome methylation, which plays
an important role in epigenetically regulated gene expression and repression. Mouse …