DNA methyltransferases (DNMTs) are an evolutionarily conserved family of DNA
methylases, transferring a methyl group onto the fifth carbon of a cytosine residue. The …

During hematopoiesis, a unique hematopoietic stem cell (HSC) from the bone marrow gives
rise to a subset of mature blood cells that directs all the immune responses. Recent studies …

SINCE ITS FIRST recognition in 1948, the fifth base of human DNA, 5-methylcytosine (5-mC)
has generated much interest and considerable controversy during attempts to understand its …

Aberrant DNA methylation is a characteristic feature of cancers including blood
malignancies. Mutations in the DNA methylation regulators DNMT3A, TET1/2, and IDH1/2 …

In recent years, an explosion of interest for genome methylation in hematopoietic stem cells
(HSCs) differentiation and transplantation has been observed. The differentiation and timely …

OBJECTIVE: To examine DNA methylation in mouse hemopoiesis before and after in vivo
exposure to a leukemogenic dose of x-rays, and address whether methylation levels are …

DNA methylation changes are among the most common detectable abnormalities in human
neoplasia. Hypermethylation within the promoters of selected genes appears to be …

The modification of DNA by cytosine methylation is crucial for normal development. DNA
methylation patterns are distinctive between tissues and are maintained with high fidelity …

DNA methylation is among the best studied epigenetic modifications and is essential to
mammalian development. Although the methylation status of most CpG dinucleotides in the …

DNA methylation is of paramount importance for mammalian embryonic development. DNA
methylation has numerous functions: it is implicated in the repression of transposons and …