DNA demethylation: where genetics meets epigenetics

X Zhang, R Fu, J Yu, X Wu - Current Pharmaceutical Design, 2014 - ingentaconnect.com
Epigenetic regulation is essential to the well-being of developing as well as developed cells
by providing tissue-specific gene expression. DNA methylation on cytosine nucleotides is …

5-Hydroxymethylcytosine is an essential intermediate of active DNA demethylation processes in primary human monocytes

M Klug, S Schmidhofer, C Gebhard, R Andreesen… - Genome biology, 2013 - Springer
Background Cytosine methylation is a frequent epigenetic modification restricting the activity
of gene regulatory elements. Whereas DNA methylation patterns are generally inherited …

DNA methylation and cancer

H Yoshikawa - Gan to Kagaku ryoho. Cancer & Chemotherapy, 2007 - europepmc.org
Tumor suppressor genes can be silenced by DNA methylation during cancer development.
Aberrant DNA methylation is closely associated with histone deacetylases and histone …

[PDF][PDF] DNA methylation dynamics during in vivo differentiation of blood and skin stem cells

C Bock, I Beerman, WH Lien, ZD Smith, H Gu, P Boyle… - Molecular cell, 2012 - cell.com
DNA methylation is a mechanism of epigenetic regulation that is common to all vertebrates.
Functional studies underscore its relevance for tissue homeostasis, but the global dynamics …

DNA methylation in blood—potential to provide new insights into cell biology

D Macartney-Coxson, AM Cameron, J Clapham… - Plos one, 2020 - journals.plos.org
Epigenetics plays a fundamental role in cellular development and differentiation; epigenetic
mechanisms, such as DNA methylation, are involved in gene regulation and the exquisite …

DNA methylation as a pathogenic event and as a therapeutic target in AML

T Schoofs, C Müller-Tidow - Cancer treatment reviews, 2011 - Elsevier
DNA methylation and its influence on gene expression are key in understanding cancer
pathogenesis. Even though it is becoming clear that DNA methylation strongly interacts with …

Regulation and function of mammalian DNA methylation patterns: a genomic perspective

H Wu, J Tao, YE Sun - Briefings in Functional Genomics, 2012 - academic.oup.com
Mammalian DNA methyltransferases (DNMTs) establish and maintain genomic DNA
methylation patterns that are required for proper epigenetic regulation of gene expression …

MDS and secondary AML display unique patterns and abundance of aberrant DNA methylation

ME Figueroa, L Skrabanek, Y Li… - Blood, The Journal …, 2009 - ashpublications.org
Increasing evidence shows aberrant hypermethylation of genes occurring in and potentially
contributing to pathogenesis of myeloid malignancies. Several of these diseases, such as …

DNA methylation dynamics in health and disease

Y Bergman, H Cedar - Nature structural & molecular biology, 2013 - nature.com
DNA methylation is an epigenetic mark that is erased in the early embryo and then re-
established at the time of implantation. In this Review, dynamics of DNA methylation during …

Expression levels of DNA methyltransferase genes do not correlate with p15INK4B gene methylation in myelodysplastic syndromes

E Aoki, H Ohashi, T Uchida, T Murate, H Saito… - Leukemia, 2003 - nature.com
The notion that gene silencing after methylation of promoters of tumor suppresser genes
results in carcinogenesis is supported by many lines of evidence. Myelodysplastic syndrome …