Background Cytosine methylation is a frequent epigenetic modification restricting the activity
of gene regulatory elements. Whereas DNA methylation patterns are generally inherited …

Tumor suppressor genes can be silenced by DNA methylation during cancer development.
Aberrant DNA methylation is closely associated with histone deacetylases and histone …

DNA methylation is a mechanism of epigenetic regulation that is common to all vertebrates.
Functional studies underscore its relevance for tissue homeostasis, but the global dynamics …

Epigenetics plays a fundamental role in cellular development and differentiation; epigenetic
mechanisms, such as DNA methylation, are involved in gene regulation and the exquisite …

DNA methylation and its influence on gene expression are key in understanding cancer
pathogenesis. Even though it is becoming clear that DNA methylation strongly interacts with …

Mammalian DNA methyltransferases (DNMTs) establish and maintain genomic DNA
methylation patterns that are required for proper epigenetic regulation of gene expression …

Increasing evidence shows aberrant hypermethylation of genes occurring in and potentially
contributing to pathogenesis of myeloid malignancies. Several of these diseases, such as …

DNA methylation is an epigenetic mark that is erased in the early embryo and then re-
established at the time of implantation. In this Review, dynamics of DNA methylation during …

The notion that gene silencing after methylation of promoters of tumor suppresser genes
results in carcinogenesis is supported by many lines of evidence. Myelodysplastic syndrome …

The methylation of DNA helps stabilize chromatin in an inactive configuration and inhibits
gene transcription. This mechanism of gene regulation is involved in essential genetic …